10494 Results for "

SelK peptide substrate

" in MedChemExpress (MCE) Product Catalog:
Products (10494)

10494 Results for "SelK peptide substrate" in MCE Product Catalog:

2335
MG-132
MG-132
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2335 Publications Verification
Cat. No.: HY-13259
CAS No.: 133407-82-6
Purity:  99.90%
Synonyms: Z-Leu-Leu-Leu-al; MG132
Target:  

Proteasome Autophagy Apoptosis

Research Areas:  

Cancer

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .
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275
740 Y-P
740 Y-P
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275 Cited Publications
Cat. No.: HY-P0175
CAS No.: 1236188-16-1
Synonyms: 740YPDGFR; PDGFR 740Y-P
Target:  

PI3K Autophagy

Research Areas:  

Cancer

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .
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266
Angiotensin II human
Angiotensin II human
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266 Cited Publications
Cat. No.: HY-13948
CAS No.: 4474-91-3
Purity:  99.98%
Synonyms: Angiotensin II; Ang II; DRVYIHPF
Category:  

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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266
Angiotensin II human acetate
Angiotensin II human acetate
0 Images
266 Cited Publications
Cat. No.: HY-13948A
CAS No.: 68521-88-0
Purity:  99.62%
Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate
Target:  

Angiotensin Receptor Apoptosis

Research Areas:  

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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266
Angiotensin II human TFA
Angiotensin II human TFA
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266 Cited Publications
Cat. No.: HY-13948B
CAS No.: 2761969-44-0
Purity:  98.84%
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
Target:  

Angiotensin Receptor Apoptosis

Research Areas:  

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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223
Cyclosporin A
Cyclosporin A
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223 Cited Publications
Cat. No.: HY-B0579
CAS No.: 59865-13-3
Synonyms: Cyclosporine A; Ciclosporin A; CsA
Category:  

Natural Products Anti-aging Microorganism Disease Research Fields Inflammation/Immunology Cancer

Target:  

Molecular Glues Complement System Antibiotic Cyclophilin

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .
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204
Ultra High Sensitivity ECL Kit
Ultra High Sensitivity ECL Kit
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204 Cited Publications
Cat. No.: HY-K1005

MCE Ultra High Sensitivity ECL Kit is an ultra-sensitive, luminol-based enhanced chemiluminescent substrate for detecting horseradish peroxidase (HRP) labeled antibodies on western blots. The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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197
Thiazolyl Blue
Thiazolyl Blue
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197 Cited Publications
Cat. No.: HY-15924
CAS No.: 298-93-1
Synonyms: MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .
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183
Docetaxel
Docetaxel
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183 Cited Publications
Cat. No.: HY-B0011
CAS No.: 114977-28-5
Synonyms: RP-56976
Category:  

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:  

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .
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183
Docetaxel Trihydrate
Docetaxel Trihydrate
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183 Cited Publications
Cat. No.: HY-B0011A
CAS No.: 148408-66-6
Synonyms: RP-56976 Trihydrate
Target:  

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:  

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .
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182
TGF beta 1/TGFB1 Protein, Human (CHO)
TGF beta 1/TGFB1 Protein, Human (CHO)
0 Images
182 Cited Publications
Cat. No.: HY-P7118
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFB1; Transforming Growth Factor Beta1; Prev. TGFB; Camurati-Engelmann Disease; Prev. DPD1; Latency-Associated peptide; TGFbeta; TGF-Beta-1; CED; TGF-Beta1; Transforming Growth Factor Beta-1 Proprotein; IBDIMDE; Prepro-Transforming Growth Factor Beta-1;
Species:  
Human
Source:  
CHO
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153
D-Luciferin sodium
D-Luciferin sodium
0 Images
153 Cited Publications
Cat. No.: HY-12591
CAS No.: 103404-75-7
Purity:  99.92%
Synonyms: D-(-)-Luciferin sodium; Firefly luciferin sodium; Beetle Luciferin sodium
D-luciferin sodium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .
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153
D-Luciferin
D-Luciferin
0 Images
153 Cited Publications
Cat. No.: HY-12591A
CAS No.: 2591-17-5
Purity:  99.54%
Synonyms: D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin
Category:  

Natural Products Animal Other Diseases Disease Research Fields

Target:  

Fluorescent Dye

D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .
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153
D-Luciferin potassium
D-Luciferin potassium
0 Images
153 Cited Publications
Cat. No.: HY-12591B
CAS No.: 115144-35-9
Purity:  99.97%
Synonyms: D-(-)-Luciferin potassium; Firefly luciferin potassium; Beetle Luciferin potassium
D-luciferin potassium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We offer the firefly luciferase (HY-P1004A), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .
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153
Caerulein
Caerulein
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153 Cited Publications
Cat. No.: HY-A0190
CAS No.: 17650-98-5
Synonyms: Ceruletide; Cerulein; FI-6934
Category:  

Cardiovascular Disease Alkaloids Animal Disease Research Fields Endocrinology Indole Alkaloids

Target:  

Cholecystokinin Receptor

Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts .
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139
GsMTx4
GsMTx4
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139 Cited Publications
Cat. No.: HY-P1410
CAS No.: 1209500-46-8
Target:  

TRP Channel Piezo Channel

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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139
GsMTx4 TFA
GsMTx4 TFA
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139 Cited Publications
Cat. No.: HY-P1410A
Target:  

TRP Channel Piezo Channel

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology .
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112
Vancomycin hydrochloride
Vancomycin hydrochloride
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112 Cited Publications
Cat. No.: HY-17362
CAS No.: 1404-93-9
Category:  

Disease Research Antibacterial Other Antibiotics Plant Cell Culture Antibiotics Phenols Polyphenols Microorganism Disease Research Fields Cancer

Target:  

Bacterial Autophagy Antibiotic

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.
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112
Vancomycin
Vancomycin
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112 Cited Publications
Cat. No.: HY-B0671
CAS No.: 1404-90-6
Category:  

Disease Research Antibacterial Endogenous metabolite Other Antibiotics Infection Human Gut Microbiota Metabolites Plant Cell Culture Antibiotics Microorganism Disease Research Fields Cancer

Target:  

Bacterial Autophagy Antibiotic

Vancomycin is an antibiotic for the treatment of bacterial infections.
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109
Insulin (human)
Insulin (human)
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109 Cited Publications
Cat. No.: HY-P0035
CAS No.: 11061-68-0
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease Endocrinology

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus .
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