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32 Results for "

Senescent cells

" in MedChemExpress (MCE) Product Catalog:

Products (32)

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GSK-3484862

28 Publications Verification

Cat. No.: HY-135146

CAS No.: 2170136-65-7

Purity: 99.95%

Synonyms: (R)-GSK3482364

Target:

DNA Methyltransferase Apoptosis

Research Areas:

Cancer

GSK-3484862 is a highly potent non-covalent inhibitor and demethylating agent of DNMT1. GSK-3484862 induces genome-wide DNA demethylation, including the regulatory elements of DNMT3B and the promoter region of TERT, and significantly inhibits cell viability, growth, proliferation and self-renewal. GSK-3484862 blocks the transformation of young AT2 cells, induces apoptosis, and generates transcriptomic features similar to those of senescent cells. GSK-3484862 is widely used in studies related to lung cancer, oral squamous cell carcinoma and lung adenocarcinoma .

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SSK1

4 Cited Publications

Cat. No.: HY-138936

CAS No.: 2629250-69-5

Purity: 99.75%

Target:

p38 MAPK Apoptosis

Research Areas:

Inflammation/Immunology

SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis .

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FOXO4-DRI

1 Cited Publications

Cat. No.: HY-P4157

CAS No.: 2460055-10-9

Target:

MDM-2/p53 Apoptosis

Research Areas:

Metabolic Disease

FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells .

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