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146 Results for "

Serotonin Transporter

" in MedChemExpress (MCE) Product Catalog:

Products (146)

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MPP+ iodide

39 Publications Verification

Cat. No.: HY-W008719

CAS No.: 36913-39-0

Target:

Mitochondrial Metabolism

Research Areas:

Neurological Disease

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

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Escitalopram

13 Cited Publications

Cat. No.: HY-14258

CAS No.: 128196-01-0

Purity: 99.98%

Synonyms: (S)-Citalopram; (S)-(+)-Citalopram

Target:

Serotonin Transporter

Research Areas:

Neurological Disease Cancer

Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

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Escitalopram oxalate

13 Cited Publications

Cat. No.: HY-14258A

CAS No.: 219861-08-2

Purity: 99.88%

Synonyms: (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate

Target:

Serotonin Transporter

Research Areas:

Neurological Disease Cancer

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

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Vortioxetine

11 Cited Publications

Cat. No.: HY-15414

CAS No.: 508233-74-7

Purity: 98.61%

Synonyms: Lu AA 21004

Target:

5-HT Receptor Serotonin Transporter

Research Areas:

Infection Neurological Disease Cancer

Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM) .

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Imipramine hydrochloride

8 Cited Publications

Cat. No.: HY-B1490

CAS No.: 113-52-0

Target:

Serotonin Transporter Apoptosis Autophagy

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects .

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Imipramine

8 Cited Publications

Cat. No.: HY-B1490A

CAS No.: 50-49-7

Target:

Serotonin Transporter Autophagy Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

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