38

OSS_128167

38 Publications Verification

Cat. No.: HY-107454

CAS No.: 887686-02-4

Purity: 98.63%

Target:

Sirtuin HBV

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .

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23

Suramin sodium salt

23 Cited Publications

Cat. No.: HY-B0879A

CAS No.: 129-46-4

Synonyms: Suramin hexasodium salt

Target:

Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis

Research Areas:

Infection Cardiovascular Disease Cancer

Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor . Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

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14

Sirtinol

14 Cited Publications

Cat. No.: HY-13515

CAS No.: 410536-97-9

Target:

Sirtuin Autophagy Apoptosis

Research Areas:

Cancer

Sirtinol is a sirtuin (SIRT) inhibitor, with IC₅₀s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively .

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10

MC3482

10 Cited Publications

Cat. No.: HY-112587

CAS No.: 2922280-86-0

Purity: 98.58%

Target:

Sirtuin

Research Areas:

Cancer

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

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5

SIRT5 inhibitor 1

5 Cited Publications

Cat. No.: HY-112634

CAS No.: 2166487-21-2

Purity: 99.65%

Target:

Sirtuin

Research Areas:

Others

SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC₅₀ of 0.11 μM.

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3

SIRT4-IN-1

3 Cited Publications

Cat. No.: HY-163316

CAS No.: 3030697-87-8

Target:

Sirtuin Glutamate Dehydrogenase (GLDH) PDHK

Research Areas:

Metabolic Disease Cancer

SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC₅₀ of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD ⁺. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .

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2

2-APQC

2 Cited Publications

Cat. No.: HY-158426

CAS No.: 500271-63-6

Purity: 99.70%

Target:

Sirtuin

Research Areas:

Cardiovascular Disease

2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (K_d=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure .

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1

Sirt2-IN-1

1 Cited Publications

Cat. No.: HY-112427

CAS No.: 1862238-00-3

Purity: 98.71%

Target:

Sirtuin

Research Areas:

Inflammation/Immunology Cancer

Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC₅₀ of 163 nM .

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Suramin

Cat. No.: HY-B0879

CAS No.: 145-63-1

Target:

Phosphatase Sirtuin Reverse Transcriptase Topoisomerase SARS-CoV Parasite Apoptosis

Research Areas:

Infection Cardiovascular Disease Cancer

Suramin is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor . Suramin is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM) . Suramin is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM) . Suramin is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor .Suramin efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent .

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TD034

Cat. No.: HY-176542

CAS No.: 3030718-42-1

Target:

HDAC YAP

Research Areas:

Cancer

TD034 is a selective, reversible and noncovalent HDAC11 inhibitor with an IC₅₀ of 5.1 nM and a K_i of 1.5 nM. TD034 does not inhibit other HDACs or sirtuins. TD034 inhibits the defatty acylation of SHMT2 (HDAC11 substrate). TD034 decreases the YAP1 level via HDAC11 inhibition. TD034 can be used for the study of lung cancer .

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