11

11 Cited Publications

Cat. No.: HY-P1902

Category:

Cardiovascular Disease Natural Products Animals Disease Research Fields

Target:

Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

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11

Cardiotoxin Analog (CTX) IV (6-12) TFA

11 Cited Publications

Cat. No.: HY-P1902A

CAS No.: 2918768-05-3

Category:

Pyrrole Alkaloids Animals Other Diseases Disease Research Fields

Target:

Apoptosis

Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

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Echistatin

Cat. No.: HY-P1189

CAS No.: 154303-05-6

Category:

Natural Products Animals Disease Research Fields Inflammation/Immunology

Target:

Integrin

Echistatin is a naturally derived RGD-containing snake venom peptide. Echistatin exhibits an IC₅₀ of 0.6 nM against mouse α_vβ₃ integrin, and acts as an antagonist against α_vβ₃, α_IIbβ₃, α₅β₁ integrins, pp125 ^FAK and paxillin. Echistatin reduces the phosphorylation of pp125 ^FAK and paxillin, inhibits the autophosphorylation and kinase activity of pp125 ^FAK, and weakens its binding to pp60^src and paxillin. Echistatin disrupts the actin cytoskeleton and focal adhesions, induces melanoma cell detachment from fibronectin, and regulates cell adhesion and motility. Echistatin inhibits osteoclast maturation and migration, bone resorption, platelet aggregation, bone loss, as well as adhesion and metastasis of Lewis lung cancer cells; it also increases the number of osteoclasts and bone coverage area in mice with secondary hyperparathyroidism. Echistatin can be used in research related to melanoma, lung cancer and secondary hyperparathyroidism .

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Echistatin TFA

Cat. No.: HY-P1189A

Category:

Natural Products Animals Metabolic Disease Disease Research Fields Inflammation/Immunology

Target:

Integrin

Echistatin TFA is a naturally derived RGD-containing snake venom peptide. Echistatin TFA exhibits an IC₅₀ of 0.6 nM against mouse α_vβ₃ integrin, and acts as an antagonist against α_vβ₃, α_IIbβ₃, α₅β₁ integrins, pp125 ^FAK and paxillin. Echistatin TFA reduces the phosphorylation of pp125 ^FAK and paxillin, inhibits the autophosphorylation and kinase activity of pp125 ^FAK, and weakens its binding to pp60^src and paxillin. Echistatin TFA disrupts the actin cytoskeleton and focal adhesions, induces melanoma cell detachment from fibronectin, and regulates cell adhesion and motility. Echistatin TFA inhibits osteoclast maturation and migration, bone resorption, platelet aggregation, bone loss, as well as adhesion and metastasis of Lewis lung cancer cells; it also increases the number of osteoclasts and bone coverage area in mice with secondary hyperparathyroidism. Echistatin TFA can be used in research related to melanoma, lung cancer and secondary hyperparathyroidism .

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AZD2716

Cat. No.: HY-120078

CAS No.: 1845753-81-2

Target:

Phospholipase

Research Areas:

Cardiovascular Disease

AZD2716 is an orally active secretory phospholipase A₂ (sPLA₂) inhibitor. AZD2716 inhibits human GIIA sPLA₂ (IC₅₀=10 nM), human GV sPLA₂ (IC₅₀=40 nM), human GX sPLA₂ (IC₅₀=400 nM), snake venom sPLA₂ (IC₅₀=2 pM), and snake (Bothrops jararacussu) Lys49-PLA2-like toxin (K_d=110 μM). AZD2716 inhibits sPLA₂ isoforms IIa, V, X, snake venom sPLA₂s, and snake venom Lys49-PLA₂-like toxin myotoxic activity via hydrophobic channel binding. AZD2716 suppresses GIIA sPLA₂ production, neutralizes snake venom-induced myotoxicity, and improves survival in envenomed mice. AZD2716 can be used for the research of coronary artery disease, atherosclerosis, and snakebite envenoming .

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CME-carbodiimide

Cat. No.: HY-W013741

CAS No.: 2491-17-0

CME-carbodiimide is a nucleic acid modification reagent. CME-carbodiimide reacts specifically with uracil and guanine residues of RNA, as well as guanine and thymine residues of denatured DNA; it does not react with native DNA. Modification of DNA by CME-carbodiimide inhibits phosphodiester bond cleavage or DNA hydrolysis mediated by pancreatic ribonuclease, snake venom phosphodiesterase and deoxyribonuclease .

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Calciseptine

Cat. No.: HY-P3269

CAS No.: 178805-91-9

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease

Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC₅₀ value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases_[1].

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7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid

Cat. No.: HY-23909

CAS No.: 89560-01-0

Synonyms: DEDA

Target:

Phospholipase

Research Areas:

Inflammation/Immunology

7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA), a phospholipase inhibitor, is a non-metabolizable analog of arachidonic or eicosadienoic acid. 7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA) inhibits P388D1 cell phospholipase A₂ (PLA₂) (IC₅₀ = 16 µM) and snake venom PLA₂ (IC₅₀ = 14 µM) .

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Hydrostatin-TL1

Cat. No.: HY-P11214

CAS No.: 2243975-43-9

Synonyms: H-TL1

Target:

TNF Receptor Integrin NF-κB ERK p38 MAPK JNK Interleukin Related

Research Areas:

Inflammation/Immunology

Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research .

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Snake poison protein

Cat. No.: HY-NP024

Snake poison protein is a venom protein secreted by the salivary glands of venomous snakes .

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DC-174

Cat. No.: HY-176241

Target:

Others

Research Areas:

Cardiovascular Disease

DC-174 is an orally active inhibitor of snake venom metalloproteinases (SVMP) with a broad spectrum of inhibitory activity against a variety of snake venom SVMPs. DC-174 acts directly on the active site of SVMPs via zinc-binding groups, inhibiting their enzymatic activity and procoagulant toxicity. DC-174 can significantly prolong the survival time of mice attacked by snake venom. DC-174 can be used in the study of first aid for snake bites .

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