26

26 Publications Verification

CAS No.: 51987-99-6

Target:

Research Areas:

TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

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26

TGN-020 sodium

26 Publications Verification

Cat. No.: HY-W008574A

CAS No.: 1313731-99-5

Target:

PROTAC Linkers

Research Areas:

Inflammation/Immunology Cancer

TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .

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18

Branaplam

18 Cited Publications

Cat. No.: HY-19620

CAS No.: 1562338-42-4

Synonyms: LMI070; NVS-SM1

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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18

Branaplam hydrochloride

18 Cited Publications

Cat. No.: HY-19620A

CAS No.: 1562338-39-9

Synonyms: LMI070 hydrochloride; NVS-SM1 hydrochloride

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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16

Z-LEHD-FMK

16 Cited Publications

Cat. No.: HY-P1010

CAS No.: 210345-04-3

Target:

Caspase Apoptosis

Research Areas:

Neurological Disease Cancer

Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma .

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10

Naloxone hydrochloride

10 Cited Publications

Cat. No.: HY-17417

CAS No.: 357-08-4

Target:

Opioid Receptor

Research Areas:

Neurological Disease

Naloxone hydrochloride is an orally active opioid receptor antagonist. Naloxone hydrochloride attenuates spinal cord stimulation‑associated anti‑hyperalgesic effects, antagonizes physiologic effects of endogenous opioid peptides linked to central nervous system injury sequelae, functions as a pressor agent to induce modest elevations in mean arterial blood pressure, exerts neuroprotective effects to improve post‑traumatic neurologic motor function, blocks opioid receptor‑mediated amnesic pathways, enhances memory consolidation, reverses Adrenocorticotropic hormone (ACTH) (HY-106373)- and epinephrine‑induced amnesia, and potentiates the memory‑facilitatory effects of ACTH and epinephrine .

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10

Naloxone

10 Cited Publications

Cat. No.: HY-17417A

CAS No.: 465-65-6

Target:

Opioid Receptor

Research Areas:

Neurological Disease

Naloxone hydrochloride is an orally active opioid receptor antagonist. Naloxone hydrochloride attenuates spinal cord stimulation‑associated anti‑hyperalgesic effects, antagonizes physiologic effects of endogenous opioid peptides linked to central nervous system injury sequelae, functions as a pressor agent to induce modest elevations in mean arterial blood pressure, exerts neuroprotective effects to improve post‑traumatic neurologic motor function, blocks opioid receptor‑mediated amnesic pathways, enhances memory consolidation, reverses Adrenocorticotropic hormone (ACTH) (HY-106373)‑ and epinephrine‑induced amnesia, and potentiates the memory‑facilitatory effects of ACTH and epinephrine .

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8

Ropivacaine mesylate

8 Cited Publications

Cat. No.: HY-B0563C

CAS No.: 854056-07-8

Target:

Sodium Channel Potassium Channel

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup . Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane .

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7

Nusinersen

7 Cited Publications

Cat. No.: HY-112980

CAS No.: 1258984-36-9

Purity: 97.79%

Target:

DNA/RNA Synthesis

Research Areas:

Neurological Disease

Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy .

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7

Nusinersen sodium

7 Cited Publications

Cat. No.: HY-112980A

Purity: 98.91%

Target:

DNA/RNA Synthesis

Research Areas:

Neurological Disease

Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen sodium improves spinal muscular atrophy .

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7

TCID

7 Cited Publications

Cat. No.: HY-18638

CAS No.: 30675-13-9

Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione

Target:

Deubiquitinase

Research Areas:

Neurological Disease

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC₅₀ of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .

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