30

Concanamycin A

30 Publications Verification

Cat. No.: HY-N1724

CAS No.: 80890-47-7

Synonyms: Antibiotic X 4357B; Folimycin; X 4357B

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Proton Pump Bacterial Antibiotic

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

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30

Concanamycin A (purity≥70%)

30 Publications Verification

Cat. No.: HY-N1724A

CAS No.: 80890-47-7

Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)

Category:

Microorganisms Antibiotics

Target:

Proton Pump Bacterial Antibiotic

Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

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12

Lifitegrast

12 Cited Publications

Cat. No.: HY-19344

CAS No.: 1025967-78-5

Synonyms: SAR 1118; SHP-606

Target:

Integrin

Research Areas:

Inflammation/Immunology

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast can be used for researching dry eye disease .

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12

Lifitegrast sodium

12 Cited Publications

Cat. No.: HY-19344A

CAS No.: 1119276-80-0

Synonyms: SAR 1118 sodium; SHP-606 sodium

Target:

Integrin

Research Areas:

Inflammation/Immunology

Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC₅₀ of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease .

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8

QS-21-Api

8 Cited Publications

Cat. No.: HY-101092

CAS No.: 141256-04-4

Purity: 99.67%

Synonyms: Stimulon

Category:

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

NOD-like Receptor (NLR)

QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

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3

Soquelitinib

3 Cited Publications

Cat. No.: HY-150298

CAS No.: 2226636-04-8

Purity: 99.71%

Synonyms: CPI-818

Target:

Itk

Research Areas:

Inflammation/Immunology Cancer

Soquelitinib (CPI-818) is an orally active and highly selective covalent interleukin-2-inducible kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytokine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 ⁺ cells that possess enhanced T effector function .

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