111

111 Publications Verification

Purity: 99.93%

Synonyms: FK506; Fujimycin; FR900506

Category:

Infection Microorganisms Animals Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

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111

Tacrolimus monohydrate

111 Publications Verification

Cat. No.: HY-13756A

CAS No.: 109581-93-3

Purity: 99.67%

Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate

Category:

Infection Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

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15

Mycophenolate mofetil hydrochloride

15 Cited Publications

Cat. No.: HY-B0199A

CAS No.: 116680-01-4

Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride

Category:

Monophenols Phenols Endogenous metabolite Disease Research Fields Cancer

Target:

Interleukin Related

Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection) .

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12

IL-17A Protein, Human (HEK293, His)

12 Cited Publications

Cat. No.: HY-P70527

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL17A; Cytotoxic T-lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-lymphocyte-Assoc

Species:

Human

Source:

HEK293

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10

Osteopontin/OPN Protein, Human (HEK293, His)

10 Cited Publications

Cat. No.: HY-P70499

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: SPP1; Uropontin; Prev. BNSP; Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein; Prev. OPN; CDNA FLJ54682, Highly Similar To Osteopontin; Osteopontin; Secreted Phosphoprotein 1 Variant 6; Lnc-PKD2-2-3; Bone Sialoprotein I; ETA-1; SPP1/CALPHA1 Fusion; BSPI; Bone Sialoprotein 1; Early T-lymphocyte Activation 1; SPP-1; Urinary Stone Protein; Opn; Nephropontin; Secreted Phosphoprotein 1; Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-lymphocyte Activation 1)

Species:

Human

Source:

HEK293

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9

Cintirorgon

9 Cited Publications

Cat. No.: HY-104037

CAS No.: 2055536-64-4

Purity: 99.14%

Synonyms: LYC-55716

Target:

ROR

Research Areas:

Cancer

Cintirorgon (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival .

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6

IL-17A Protein, Human

6 Cited Publications

Cat. No.: HY-P7036

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL17A; Cytotoxic T-lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-lymphocyte-Associated Antigen 8

Species:

Human

Source:

E. coli

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5

Ipilimumab

5 Cited Publications

Cat. No.: HY-P9901

CAS No.: 477202-00-9

Synonyms: MDX-010; BMS-734016

Ipilimumab is a fully human monoclonal antibody IgG1κ that blocks the inhibitory receptor cytotoxic T lymphocyte antigen 4 (CTLA-4) on T cells. Ipilimumab can be used in unresectable or metastatic melanoma (MM) studies .

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5

IL-17A Protein, Mouse (HEK293, His)

5 Cited Publications

Cat. No.: HY-P70753

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL17A; Cytotoxic T-lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-lymphocyte-Assoc

Species:

Mouse

Source:

HEK293

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4

CD86 Antibody

4 Cited Publications

Cat. No.: HY-P80609

Synonyms: CD86; CD28LG2; T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD antigen CD86

Host:

Rabbit

Application:

WB, IHC-P, ICC/IF, IP, FC

Reactivity:

Human, Rat

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4

LCMV gp33-41

4 Cited Publications

Cat. No.: HY-P1569

CAS No.: 151705-84-9

Synonyms: LCMV GP(33-41) M-peptide; gp33 epitope

Target:

Arenavirus

Research Areas:

Infection Inflammation/Immunology

LCMV gp33-41, the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .

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4

LCMV gp33-41 TFA

4 Cited Publications

Cat. No.: HY-P1569A

Synonyms: LCMV GP(33-41) M-peptide TFA; gp33 epitope TFA

Target:

Arenavirus

Research Areas:

Inflammation/Immunology

LCMV gp33-41 (TFA), the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .

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3

IL-17A Protein, Rat (CHO)

3 Cited Publications

Cat. No.: HY-P79326

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL17A; Cytotoxic T-lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-lymphocyte-Assoc

Species:

Rat

Source:

CHO

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3

Animal-Free IL-17A Protein, Mouse (His)

3 Cited Publications

Cat. No.: HY-P700194AF

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IL17A; Cytotoxic T-lymphocyte-Associated Protein 8; Prev. CTLA8; Interleukin-17A; Prev. IL17; CTLA-8; IL-17A; Interleukin-17; IL-17; ILA17; Interleukin 17 (Cytotoxic T-lymphocyte-Associated Serine Esterase 8); Interleukin 17A; Cytotoxic T-lymphocyte-Assoc

Species:

Mouse

Source:

E. coli

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3

Dehydrocostus Lactone

3 Cited Publications

Cat. No.: HY-N0591

CAS No.: 477-43-0

Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide

Category:

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