Target:

Research Areas:

TCL1 is a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit in the 19S regulatory particle (19S RP) of the proteasome with an IC₅₀ value of approximately 26 μM. TCL1 interferes with the recognition and transport of ubiquitinated proteins by Rpn-13, inhibits the degradation of proteins by the proteasome, and thus affects the balance of intracellular protein metabolism. TCL1 is promising for research of hematological malignancies .

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ILK-IN-2

Cat. No.: HY-18676B

CAS No.: 1333146-24-9

Synonyms: OSU-T315 analog

Target:

Integrin Autophagy Apoptosis Caspase PDHK

Research Areas:

Cancer

ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC₅₀ of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models .

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TCL1(10-24)

Cat. No.: HY-P10105

CAS No.: 835655-37-3

Target:

Akt Apoptosis

Research Areas:

Cancer

TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo .

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TAT-TCL1-Akt-in

Cat. No.: HY-P10049

CAS No.: 1073630-46-2

Target:

Akt

Research Areas:

Cancer

TAT-TCL1-Akt-in is an Akt inhibitor .

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TCL1A Human Pre-designed siRNA Set A

Cat. No.: HY-RS14316

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

TCL1A Human Pre-designed siRNA Set A contains three designed siRNAs for TCL1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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TCL1B Human Pre-designed siRNA Set A

Cat. No.: HY-RS14317

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

TCL1B Human Pre-designed siRNA Set A contains three designed siRNAs for TCL1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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TCL1-PEG4-C2-NH2

Cat. No.: HY-187440

CAS No.: 3119089-68-5

Target:

Target Protein Ligand-Linker Conjugates Proteasome

Research Areas:

Others

TCL1-PEG4-C2-NH2 (Compound 3) is a conjugate of a Rpn13 ligand and a linker, which can be used to synthesize PROTACs such as Truly-4 (HY-187439) .

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T Cell Leukemia/Lymphoma Protein 1A Antibody (YA5620)

Cat. No.: HY-P85928

Synonyms: Anti TCL1A; Lymphoma/leukemia, T-cell; Oncogene TCL-1; Oncogene TCL1; P14 TCL1; P14 TCL1 protein; Protein p14 TCL1; T cell leukemia 1; T cell lymphoma 1; T cell lymphoma 1A; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; TCL 1 protein; TCL1; TCL1 oncogene; TCL1 PEN; TCL1a; TCL1A; TCL1A_HUMAN

Host:

Mouse

Application:

IHC-P, WB, ICC/IF, ELISA

Reactivity:

Human

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TCL1A Protein, Human (His)

Cat. No.: HY-P74530

Purity: ≥ 85%, as determined by reducing SDS-PAGE.

Synonyms: TCL1A; Protein P14 TCL1; TCL1 Family AKT Coactivator A; Oncogene TCL-1; TCL1; Oncogene TCL1; T-Cell Leukemia/Lymphoma Protein 1A; T-Cell Lymphoma-1; T Cell Leukemia/Lymphoma 1A

Species:

Human

Source:

E. coli

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Tcl1a Rat Pre-designed siRNA Set A

Cat. No.: HY-RS25978

Target:

Small Interfering RNA (siRNA)

Research Areas:

Others

Tcl1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tcl1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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