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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
THNAN 69
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "THNAN 69" in MCE Product Catalog:
Cat. No.: HY-178122
Research Areas:
THNAN69 is a PROTAC degrader targeting LIMK2, which efficiently degrades ectopically expressed EGFP-LIMK2 in live HuCCT1 cells with a DC50 of 1 nM. THNAN69 induces isoform-specific ubiquitin-mediated degradation of LIMK2 by recruiting the CRBN E3 ligase, forming a stable ternary complex with LIMK2 and CRBN; this degradation process depends on the activity of cullin-RING ligase. THNAN69 does not reduce phosphorylated cofilin levels, as LIMK1 can compensate for the loss of LIMK2; it also stimulates compensatory activation of the Rho signaling pathway including PAK1/2 and ROCK1/2. THNAN69 serves as a selective chemical probe for dissecting the LIMK2 isoform-dependent biological mechanisms. THNAN69 can be used in the research of cholangiocellular carcinoma and acute lymphoblastic leukemia .
Cat. No.: HY-189496
Research Areas:
LIMK2 ligand-Linker Conjugate 1 is a LIMK2-targeting ligand-linker conjugate. LIMK2 ligand-Linker Conjugate 1 can be used for the synthesis of the LIMK2-targeting PROTAC degrader THNAN69 (HY-178122) .
Cat. No.: HY-189495
Target:
Research Areas:
CRBN ligand-911 is an E3 ligase ligand that targets CRBN. CRBN ligand-911 forms a stable ternary complex with CRBN to enable proximity-induced co-binding and ubiquitination of LIMK2. CRBN ligand-911 binds directly to CRBN. CRBN ligand-911 is used for the synthesis of the LIMK2-targeting PROTAC degrader THNAN69 (HY-178122) .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
