40 Results for "

TRAF6

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "TRAF6" in MCE Product Catalog:

29
C25-140
C25-140
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29 Publications Verification
Cat. No.: HY-120934
CAS No.: 1358099-18-9
Purity:  99.92%
Target:  

TNF Receptor E1/E2/E3 Enzyme

Research Areas:  

Inflammation/Immunology

C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity .
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14
Dexamethasone phosphate disodium
Dexamethasone phosphate disodium
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14 Cited Publications
Cat. No.: HY-B1829A
CAS No.: 2392-39-4
Synonyms: Dexamethasone 21-phosphate disodium
Target:  

Glucocorticoid Receptor TGF-β Receptor Interleukin Related

Research Areas:  

Neurological Disease Inflammation/Immunology

Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) [6].
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14
Dexamethasone phosphate
Dexamethasone phosphate
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14 Cited Publications
Cat. No.: HY-B1829
CAS No.: 312-93-6
Synonyms: Dexamethasone 21-phosphate
Target:  

Glucocorticoid Receptor TGF-β Receptor Interleukin Related

Research Areas:  

Neurological Disease Inflammation/Immunology

Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) [6].
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7
2-Ketoglutaric acid potassium
2-Ketoglutaric acid potassium
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7 Cited Publications
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC50 value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .
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4
TRAF-STOP inhibitor 6877002
TRAF-STOP inhibitor 6877002
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4 Cited Publications
Cat. No.: HY-110247
CAS No.: 433249-94-6
Purity:  99.67%
Target:  

TNF Receptor NF-κB

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

TRAF-STOP inhibitor 6877002 is a selective CD40-TRAF6 interaction inhibitor. TRAF-STOP inhibitor 6877002 exerts anti-atherosclerotic activity by blocking the CD40-TRAF6 signaling pathway, inhibiting classical monocyte activation, leukocyte recruitment, and macrophage activation and migration. TRAF-STOP inhibitor 6877002 reduces the phosphorylation levels of signaling intermediates in the canonical NF-κB pathway .
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3
Tabersonine
Tabersonine
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3 Cited Publications
Cat. No.: HY-N1431
CAS No.: 4429-63-4
Category:  

Alkaloids Plants Indole Alkaloids Apocynaceae Extract 500 - Internal Server Error | MedChemExpress

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