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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
TRF2
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "TRF2" in MCE Product Catalog:
Cat. No.: HY-169120
CAS No.: 108979-07-3
Target:
Research Areas:
FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanism in liver cancer cells, leading to T-loop defects, telomere shortening, and cellular senescence. Additionally, FKB04 can inhibit tumor growth in a human liver cancer xenograft mouse model (with Huh-7 cells implanted in BALB/c mice). FKB04 can be used in liver cancer research .
Cat. No.: HY-145748
CAS No.: 188630-47-9
Research Areas:
SYUIQ-5 is a G-quadruplex stabilizer. SYUIQ-5 stabilizes the c-myc promoter G-quadruplex, the VEGF promoter G-quadruplex, and the telomeric G-quadruplex. SYUIQ-5 selectively inhibits telomerase but not Taq polymerase, while decreasing c-myc/hTERT expression and dissociating NM23-H2. SYUIQ-5 induces growth arrest, senescence, autophagy, DNA damage response, telomere shortening, and apoptosis, accompanied by upregulation of p16/p21/p27, decreased TRF2, and pro-catabolic myotube changes. SYUIQ-5 can be used for research on leukemia, colon cancer, cervical cancer, nasopharyngeal carcinoma, Burkitt lymphoma, and sarcopenia [2] .
Cat. No.: HY-168890
CAS No.: 2486358-59-0
Target:
Research Areas:
TRF2-IN-1 (compound F2) is a potent telomere repeat-binding factor 2 (TRF2) inhibitor. TRF2-IN-1 shows antiproliferative activity. TRF2-IN-1 induces apoptosis. TRF2-IN-1 directly bind to the TRF2TRFH domain and selectively inhibits TRF2 protein expression and telomeric localization. TRF2-IN-1 shows anticancer activity. TRF2-IN-1 has the potential for the research of osteosarcoma .
Cat. No.: HY-P84591A
Synonyms: TRF2; TRBF2
Cat. No.: HY-P703224
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: TERF2; Telomeric Repeat-Binding Factor 2; Prev. TRBF2; Telomeric DNA-Binding Protein; TRF2; Telomeric Repeat Binding Protein 2; Telomeric Repeat Binding Factor 2; TTAGGG Repeat-Binding Factor 2
Species:
Human
Source:
E. coli
Cat. No.: HY-RS14373
Target:
Research Areas:
TERF2 Human Pre-designed siRNA Set A contains three designed siRNAs for TERF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14267
Target:
Research Areas:
TBPL1 Human Pre-designed siRNA Set A contains three designed siRNAs for TBPL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P810836
Synonyms: DRIP5, RAP1, PP8000, TERF2IP, Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1
Cat. No.: HY-P810838
Synonyms: DRIP5; RAP1; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; RAP1 homolog; hRap1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
