3 Results for "

TTX-R

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "TTX-R" in MCE Product Catalog:

Cat. No.: HY-157802
CAS No.: 2834106-06-6
Purity:  99.35%
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research .
loading...
    loading...
Cat. No.: HY-P5773
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC50 of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons .
loading...
    loading...
Cat. No.: HY-P5772
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC50 of 0.26 μM .
loading...
    loading...