8 Results for "

TcdB

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "TcdB" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P79219
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Toxin B; EC:3.4.22.-; Glucosyltransferase TcdB; EC:2.4.1.-; TcdB; toxB
Species:  
Others
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-148041
CAS No.: 85573-18-8
Purity:  ≥98.0%
Target:  

ATP Synthase

Research Areas:  

Others

ATPase-IN-2 is an ATPase inhibitor with an IC50 value of 0.9 μM. ATPase-IN-2 inhibits C. difficile toxin B (TcdB) glycohydrolase activity with an AC50 value of 30.91 μM. ATPase-IN-2 can be used for the research of ATP-related .
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Cat. No.: HY-107830
CAS No.: 1448-36-8
Purity:  99.81%
Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis .
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Cat. No.: HY-P99277
CAS No.: 1245634-25-6
Synonyms: Anti-C. difficile Toxin A Recombinant Antibody

Target:  

Inhibitory Antibodies

Research Areas:  

Infection

Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB .
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Cat. No.: HY-P10204
CAS No.: 2416664-25-8
Target:  

Wnt

Research Areas:  

Cancer

FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC50 value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors .
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Cat. No.: HY-107830R
CAS No.: 1448-36-8
Methyl cholate (Standard) is the analytical standard of Methyl cholate. This product is intended for research and analytical applications. Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis .
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Cat. No.: HY-W746556
CAS No.: 52886-39-2
Methyl cholate-d5 is the deuterium labeled Methyl cholate. Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis .
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Cat. No.: HY-P992123
CAS No.: 3054523-85-9
Synonyms: AZD-5148

Target:  

Bacterial

Research Areas:  

Infection

Ombetoxabart is a humanized IgG1-κ monoclonal antibody targeting TcdB (Clostridioides difficile toxin B), which exerts its function by neutralizing the toxicity of TcdB. Ombetoxabart can be used for the study of Clostridioides difficile infection .
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