9

Ritlecitinib

9 Publications Verification

Cat. No.: HY-100754

CAS No.: 1792180-81-4

Purity: 99.43%

Synonyms: PF-06651600

Target:

JAK Interleukin Related STAT

Research Areas:

Inflammation/Immunology

Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC₅₀=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC₅₀ >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .

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9

MOG (35-55) mouse, rat

9 Publications Verification

Cat. No.: HY-P1240

CAS No.: 149635-73-4

Synonyms: Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

Target:

Endogenous Metabolite

Research Areas:

Neurological Disease Inflammation/Immunology

MOG (35-55) mouse, rat (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) is a minor component of CNS myelin. MOG (35-55) mouse, rat has encephalitogenic activity and induces T cell proliferative. MOG (35-55) mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) mouse, rat (MOG (35-55)) can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

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9

MOG (35-55) TFA

9 Publications Verification

Cat. No.: HY-P1240A

Synonyms: Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA

Target:

Endogenous Metabolite

Research Areas:

Neurological Disease Inflammation/Immunology

MOG (35-55) (MOG (35-55)) TFA is a minor component of CNS myelin. MOG (35-55) (TFA) has encephalitogenic activity and induces T cell proliferative. MOG (35-55) (TFA) induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) (TFA) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) (MOG (35-55)) TFA can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

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9

MOG (35-55) acetate

9 Publications Verification

Cat. No.: HY-P1240B

Synonyms: Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate

Target:

Inhibitory Antibodies

Research Areas:

Neurological Disease Inflammation/Immunology

MOG (35-55) (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) acetate is a minor component of CNS myelin. MOG (35-55) (acetate) has encephalitogenic activity and induces T cell proliferative. MOG (35-55) (acetate) induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) (acetate) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) acetate can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

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9

Ritlecitinib tosylate

9 Publications Verification

Cat. No.: HY-100754C

CAS No.: 2192215-81-7

Purity: 99.77%

Synonyms: PF-06651600 tosylate

Target:

JAK Interleukin Related STAT

Research Areas:

Inflammation/Immunology

Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC₅₀=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC₅₀ >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .

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8

QS-21-Api

8 Cited Publications

Cat. No.: HY-101092

CAS No.: 141256-04-4

Purity: 99.67%

Synonyms: Stimulon

Category:

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:

NOD-like Receptor (NLR)

QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

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