363 Results for "

Thyroid

" in MedChemExpress (MCE) Product Catalog:
Products (363)

363 Results for "Thyroid" in MCE Product Catalog:

67
(-)-Epigallocatechin Gallate
(-)-Epigallocatechin Gallate
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67 Publications Verification
Cat. No.: HY-13653
CAS No.: 989-51-5
Purity:  99.75%
Synonyms: EGCG; Epigallocatechol Gallate
Category:  

Anti-aging Plants Other Families Extract Endogenous metabolite Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite Apoptosis

(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .
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48
Liothyronine
Liothyronine
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48 Cited Publications
Cat. No.: HY-A0070A
CAS No.: 6893-02-3
Synonyms: Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3
Category:  

Microorganisms Monophenols Ketones, Aldehydes, Acids Disease markers Endocrine diseases Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .
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48
Liothyronine sodium
Liothyronine sodium
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48 Cited Publications
Cat. No.: HY-A0070
CAS No.: 55-06-1
Synonyms: Triiodothyronine sodium; 3,3',5-Triiodo-L-thyronine sodium; T3 sodium
Category:  

Monophenols Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
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48
Liothyronine sodium hydrate
Liothyronine sodium hydrate
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48 Cited Publications
Cat. No.: HY-A0070B
CAS No.: 345957-19-9
Synonyms: Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate
Category:  

Monophenols Phenols Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Thyroid Hormone Receptor Endogenous Metabolite

Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
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26
IU1
IU1
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26 Cited Publications
Cat. No.: HY-13817
CAS No.: 314245-33-5
Purity:  99.30%
Target:  

Deubiquitinase Autophagy Apoptosis

Research Areas:  

Cardiovascular Disease Neurological Disease Endocrinology Cancer

IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
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25
Resmetirom
Resmetirom
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25 Cited Publications
Cat. No.: HY-12216
CAS No.: 920509-32-6
Purity:  99.90%
Synonyms: MGL-3196; VIA-3196
Target:  

Thyroid Hormone Receptor

Research Areas:  

Cardiovascular Disease Endocrinology

Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis .
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19
Matrine
Matrine
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19 Cited Publications
Cat. No.: HY-N0164
CAS No.: 519-02-8
Synonyms: Matridin-15-one; Vegard; α-Matrine
Category:  

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