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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
165 Results for "
Transmembrane domain
" in MedChemExpress (MCE) Product Catalog:
Products (165)
165 Results for "Transmembrane domain" in MCE Product Catalog:
5
Category:
Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
Cat. No.: HY-135416
CAS No.: 98072-47-0
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3
3 Cited Publications
NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor .
2
Taladegib is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers .
2
2 Cited Publications
F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD) .
2
Taladegib (LY2940680) hydrochloride is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib hydrochloride binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib hydrochloride can be used in studies of Hedgehog pathway-related cancers .
2
2 Cited Publications
Cat. No.: HY-P1925A
CAS No.: 1222186-26-6
Research Areas:
1
1 Cited Publications
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Research Areas:
NVS-STG2 is a molecular glue that targets STINGtransmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models .
1
1 Cited Publications
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AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .
1
1 Cited Publications
Cat. No.: HY-P10495A
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Research Areas:
1
1 Cited Publications
Target:
1
1 Cited Publications
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AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .
1
1 Cited Publications
Cat. No.: HY-P70201
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLRT2; Leucine-Rich Repeat Transmembrane Protein FLRT2; Fibronectin Leucine Rich Transmembrane Protein 2; KIAA0405; Fibronectin-Like domain-Containing Leucine-Rich Transmembrane Protein 2
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P76055
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SEMA4A; Semaphorin-4A; Prev. SEMAB; FLJ12287; CORD10; Sema B; SemB; RP35; Sema domain, Immunoglobulin domain (Ig), Transmembrane domain (TM) And Short Cytoplasmic domain, (Semaphorin) 4A; SEMB; Semaphorin 4A; Semaphorin-B
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P76057
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SEMA6A; Sema domain, Transmembrane domain (TM), And Cytoplasmic domain, (Semaphorin) 6A; Prev. SEMAQ; Sema VIa; Semaphorin VIA; SEMA6A-1; Semaphorin-6A; CDNA FLJ39018 Fis, Clone NT2RP7002594, Highly Similar To Semaphorin-6A; KIAA1368; Semaphorin 6A-1; SEM
Species:
Human
Source:
HEK293
Cat. No.: HY-153213
CAS No.: 1421683-12-6
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Research Areas:
Org 274179-0 is a low-molecular-weight allosteric thyrotropin receptor (TSH Receptor) antagonist with equipotent follicle-stimulating hormone receptor antagonistic activity and selectivity for the luteinizing hormone receptor. Org 274179-0 binds to the transmembrane domain of the thyrotropin receptor, stabilizes the receptor's inactive state, and blocks agonist-induced and constitutive signaling through the adenylyl cyclase/cAMP and phospholipase C pathways. Org 274179-0 can be used for research on Graves' disease and Graves' ophthalmopathy .
Cat. No.: HY-P1985
CAS No.: 2408730-51-6
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GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) .
Cat. No.: HY-P2508
CAS No.: 149205-73-2
NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75 NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75 NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
