77

Polyinosinic-polycytidylic acid sodium

77 Publications Verification

Cat. No.: HY-135748

CAS No.: 42424-50-0

Purity: 99.4%

Synonyms: Poly(I:C) sodium

Target:

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis .

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75

Polyinosinic-polycytidylic acid

75 Cited Publications

Cat. No.: HY-107202

CAS No.: 24939-03-5

Purity: 99.40%

Synonyms: Poly(I:C)

Target:

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis

Research Areas:

Infection Inflammation/Immunology Cancer

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis .

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25

Molibresib besylate

25 Cited Publications

Cat. No.: HY-13032B

CAS No.: 1895049-20-3

Purity: 97.04%

Synonyms: GSK 525762C; I-BET 762 besylate

Target:

Epigenetic Reader Domain ERK

Research Areas:

Cancer

Molibresib besylate (GSK 525762C; I-BET 762 besylate) is an orally active pan-BET inhibitor that targets and binds to BRD2, BRD3, BRD4 and BRDT. By competitively occupying acetylated lysine binding sites, Molibresib besylate disrupts the interaction between BET proteins and chromatin, thereby effectively inhibiting MYC expression and target gene transcription. Molibresib besylate exhibits broad antiproliferative activity, which not only inhibits cancer cell growth and induces growth arrest, but also downregulates mitosis-related genes and upregulates the level of p-ERK1/2. When combined with MEK inhibitors, Molibresib besylate shows a significant synergistic effect, reduces tumor burden in mouse models of leukemia, modulates the immune microenvironment and prolongs survival. Molibresib besylate is widely applicable to research related to acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, small-cell lung cancer and various advanced refractory solid tumors .

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16

PTC-209

16 Cited Publications

Cat. No.: HY-15888

CAS No.: 315704-66-6

Purity: 99.76%

Target:

BMI1 Autophagy

Research Areas:

Cancer

PTC-209 is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment .

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16

PTC-209 hydrobromide

16 Cited Publications

Cat. No.: HY-15888A

CAS No.: 1217022-63-3

Purity: 99.44%

Target:

BMI1 Autophagy

Research Areas:

Cancer

PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC₅₀ of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment .

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11

Poly (I:C):Kanamycin (1:1)

11 Cited Publications

Cat. No.: HY-107202A

Purity: 51.00%

Target:

Toll-like Receptor (TLR) RIG-I-like receptor (RLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis

Research Areas:

Infection Inflammation/Immunology Cancer

Poly(I:C):Kanamycin (1:1) is a mixture of Poly(I:C) (HY-107202) and Kanamycin (HY-16566). Poly(I:C) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Poly(I:C) can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Poly(I:C) can directly trigger cancer cells to undergo apoptosis. Kanamycin stabilizes Poly(I:C) .

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11

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride

11 Cited Publications

Cat. No.: HY-W074143

CAS No.: 36309-88-3

Synonyms: [Ru(DPP)3]Cl2

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride ([Ru(dpp)3] ²⁺) is an electrochemiluminescent (ECL) probe and oxygen-sensitive sensor. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride can be used to modify electrode surfaces for the detection of sulfates (S₂O₈ ^2-) and oxalates, based on electrochemical reactions that generate excited-state species, releasing photons through irreversible redox reactions. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride utilizes the oxygen quenching of fluorescence mechanism, where fluorescence intensity reflects the metabolic rate of living microorganisms or oxygen levels within cells/tumors, allowing for real-time detection. Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride's main applications include microbial detection, antibacterial activity studies, and tumor microenvironment research .

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10

5'-Methylthioadenosine

10 Cited Publications

Cat. No.: HY-16938

CAS No.: 2457-80-9

Synonyms: 5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine

Category:

Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Apoptosis Parasite

5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .

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7

CL2A-SN-38

7 Cited Publications

Cat. No.: HY-128946

CAS No.: 1279680-68-0

Purity: 99.07%

Target:

Drug-Linker Conjugates for ADC

Research Areas:

Inflammation/Immunology Cancer

CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects .

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6

STC-15

6 Cited Publications

Cat. No.: HY-156677

CAS No.: 2648257-56-9

Purity: 99.90%

Target:

METTL3

Research Areas:

Cancer

STC-15 is an orally active RNA methyltransferase METTL3 inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. STC-15 can be used in the study of proliferative diseases such as cancer and autoimmune diseases .

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