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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
U2AF
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "U2AF" in MCE Product Catalog:
Cat. No.: HY-148384
CAS No.: 2103079-87-2
Target:
Research Areas:
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a Kd of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties .
Target:
Research Areas:
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .
Cat. No.: HY-178155
Target:
Research Areas:
AP232 is a selective U2AF1-UHM Inhibitor with an IC50 of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia .
Cat. No.: HY-178155A
Target:
Research Areas:
AP232 dihydrochloride is a selective U2AF1-UHM Inhibitor with an IC50 of 7.96 μM. AP232 dihydrochloride exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 dihydrochloride exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 dihydrochloride can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 dihydrochloride can be used for the research of cancer, such as Leukemia .
Cat. No.: HY-148384A
CAS No.: 2925647-93-2
Target:
Research Areas:
UHMCP1 dihydrochloride is a potent UHM domain splicing inhibitor with a Kd value of 79 μM. UHMCP1 dihydrochloride prevents the SF3b155/U2AF 65 interaction. UHMCP1 dihydrochloride impacts cell viability and RNA splicing .
Cat. No.: HY-RS15313
Target:
Research Areas:
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS15314
Target:
Research Areas:
U2AF2 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18687
Target:
Research Areas:
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-148384B
Target:
Research Areas:
Trans-UHMCP1 is the trans-isomer of UHMCP1 (HY-148384). UHMCP1 is a chemical probe of the U2AF homologous motif (UHM), with a Kd value of 79 μM. UHMCP1 inhibits the interaction between SF3b155/U2AF 65, affecting RNA splicing and cell viability. UHMCP1 has potential anti-cancer properties .
Cat. No.: HY-P703041
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: UHMK1; U2AF Homology Motif Kinase 1; KIS; Kist; PAM COOH-Terminal Interactor Protein 2; Serine/Threonine-Protein Kinase Kist; U2AF Homology Motif (UHM) Kinase 1; P-CIP2; Kinase Interacting With Leukemia-Associated Gene (Stathmin); Kinase Interacting With
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-RS22890
Target:
Research Areas:
U2af2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25173
Target:
Research Areas:
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS29404
Target:
Research Areas:
U2af2 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703295
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: U2AF2; U2AF65; U2 SnRNP Auxiliary Factor Large Subunit; U2 Small Nuclear RNA Auxiliary Factor 2; Splicing factor U2AF 65 kDa subunit; U2 auxiliary factor 65 kDa subunit; hU2AF65; hU2AF65; U2 snRNP auxiliary factor large subunit; DEVDFB; HU2AF(65); Splicin
Species:
Human
Source:
E. coli
Cat. No.: HY-P71534
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DDX39B; DEAD-Box Helicase 39B; Prev. BAT1; HLA-B Associated Transcript 1; D6S81E; Spliceosome RNA Helicase BAT1; Uap56; U2AF65-Associated Protein 56; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39B; ATP-Dependent RNA Helicase; HLA-B-Associated Transcript 1 Pro
Species:
Human
Source:
E. coli
Cat. No.: HY-P77396
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGFLR1; IGF-Like Family Receptor 1; Prev. TMEM149; U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 4; Prev. U2AF1L4; U2 Small Nuclear RNA Auxiliary Factor 1-Like 4; Transmembrane Protein 149; IGF Like Family Receptor 1; FLJ22573
Species:
Human
Source:
HEK293
Cat. No.: HY-P700454
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGFLR1; IGF-Like Family Receptor 1; Prev. TMEM149; U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 4; Prev. U2AF1L4; U2 Small Nuclear RNA Auxiliary Factor 1-Like 4; Transmembrane Protein 149; IGF Like Family Receptor 1; FLJ22573
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
