12

Zotatifin

12 Publications Verification

Cat. No.: HY-112163

CAS No.: 2098191-53-6

Purity: 99.69%

Synonyms: eFT226

Target:

Eukaryotic Initiation Factor (eIF) SARS-CoV Apoptosis

Research Areas:

Infection Cancer

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC₅₀=2 nM) and interferes with the assembly of the eIF4F initiation complex . Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC₉₀=37 nM) . Zotatifin induces cell apoptosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Apcin

11 Cited Publications

Cat. No.: HY-110287

CAS No.: 300815-04-7

Purity: 99.62%

Target:

APC Mitosis

Research Areas:

Cancer

Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

Thrombin (MW 37kDa)

9 Cited Publications

Cat. No.: HY-114164

CAS No.: 9002-04-4

Target:

Thrombin

Research Areas:

Neurological Disease

Thrombin (MW 37kDa) is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

Thrombin, Pig blood

9 Cited Publications

Cat. No.: HY-114164C

CAS No.: 9002-04-4

Purity: 88.00%

Target:

Protease Activated Receptor (PAR) Thrombin

Research Areas:

Cardiovascular Disease

Rabbit Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

Rat Thrombin

9 Cited Publications

Cat. No.: HY-114164D

CAS No.: 9002-04-4

Target:

Thrombin

Research Areas:

Cardiovascular Disease

Rat Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

Bractoppin

3 Cited Publications

Cat. No.: HY-126020

CAS No.: 2290527-07-8

Purity: 99.90%

Target:

DNA/RNA Synthesis RAD51

Research Areas:

Cancer

Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC₅₀: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

NDI-091143

2 Cited Publications

Cat. No.: HY-127111

CAS No.: 2375840-87-0

Purity: 99.54%

Target:

ATP Citrate Lyase

Research Areas:

Cancer

NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC₅₀ of 2.1 nM (ADP-Glo assay), a K_i of 7.0 nM and a K_d of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

WAY-267464 hydrochloride

2 Cited Publications

Cat. No.: HY-108679

CAS No.: 1432043-31-6

Target:

Oxytocin Receptor

Research Areas:

Neurological Disease

WAY-267464 (hydrochloride) is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 (hydrochloride) can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 (hydrochloride) can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

WAY-267464

2 Cited Publications

Cat. No.: HY-15522

CAS No.: 847375-16-0

Target:

Oxytocin Receptor

Research Areas:

Neurological Disease

WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

ANS

2 Cited Publications

Cat. No.: HY-D0896

CAS No.: 82-76-8

Synonyms: ANSA; 8-Anilino-1-naphthalenesulfonic acid

ANS (8-Anilino-1-naphthalenesulfonic acid) is a competitive inhibitor targeting thyroxine binding globulin (TBG) (K_i=2.09×10 ⁶ M ^-1). ANS is used in radioimmunoassay by displacing bound triiodothyronine (T3) to improve detection sensitivity. ANS can block the protein binding site of T3 and release free T3 for antibody recognition. As a fluorescent probe, ANS can specifically bind to the hydrophobic region of proteins (such as membrane proteins) and monitor the dynamics of protein conformation through changes in fluorescent signals. It is widely used in biochemical research and antibacterial material development .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

TAK-418

2 Cited Publications

Cat. No.: HY-138830

CAS No.: 1818252-53-7

Purity: 99.81%

Target:

Histone Demethylase

Research Areas:

Neurological Disease

TAK-418 is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC₅₀ of 2.9 nM. TAK-418 irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .

Compare

loading...