URAT1 | MedChemExpress (MCE) Life Science Reagents

Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with K_m values of 0.85 and 2 µM, respectively.

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5

Lesinurad sodium

5 Cited Publications

Cat. No.: HY-15258A

CAS No.: 1151516-14-1

Purity: 99.97%

Synonyms: RDEA-594 sodium

Target:

OAT URAT1

Research Areas:

Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with K_m values of 0.85 and 2 μM, respectively.

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2

Verinurad

2 Cited Publications

Cat. No.: HY-16733

CAS No.: 1352792-74-5

Synonyms: RDEA3170

Target:

Research Areas:

Verinurad (RDEA3170) is a highly potent and specific URAT1 inhibitor with an IC₅₀ of 25 nM ^[1].

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Xininurad

Cat. No.: HY-147422

CAS No.: 2365178-28-3

Purity: 99.59%

Synonyms: XNW3009

Target:

Metabolic Disease Inflammation/Immunology

Research Areas:

Xininurad is a potent orally active URAT1 inhibitor with an IC₅₀ of 7.17 nM. Xininurad inhibits URAT1 activity to reduce serum uric acid levels and increase urinary uric acid excretion. Xininurad can be used for the research of hyperuricemia and gout ^[1].

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URAT1 inhibitor 8

Cat. No.: HY-153971

CAS No.: 1632005-33-4

Purity: 98.01%

Target:

Research Areas:

NOD-like Receptor (NLR) URAT1 Interleukin Related OAT GLUT

URAT1 inhibitor 8 (example 247) is a potent URAT1 inhibitor, with an IC₅₀ of 0.001 μM. URAT1 inhibitor 8 can be used for gout research ^[1].

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NLRP3/URAT1-IN-1

Cat. No.: HY-175645

CAS No.: 2994637-53-3

Target:

Research Areas:

Metabolic Disease Inflammation/Immunology

NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC₅₀ = 3.81 μM). NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS (HY-D1056) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC₅₀ of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia ^[1].

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Epaminurad

Cat. No.: HY-111345

CAS No.: 1198153-15-9

Purity: 99.75%

Synonyms: UR-1102; URC-102

Target:

OAT URAT1

Research Areas:

Metabolic Disease Inflammation/Immunology

Epaminurad (UR-1102) is an orally active, potent and selective URAT1 (urate transporter 1) inhibitor, with a K_i of 0.057 μM. Epaminurad quite modestly inhibits OAT1 and OAT3 (organic anion transporter). Epaminurad is a uricosuric agent. Epaminurad can be used for gout and hyperuricemia research ^[1].

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URAT1 inhibitor 10

Cat. No.: HY-163431

CAS No.: 3012586-38-5

Target:

Research Areas:

URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 ^[1].

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URAT1 inhibitor 5

Cat. No.: HY-153706

CAS No.: 2102670-94-8

Target:

Cardiovascular Disease Metabolic Disease

Research Areas:

URAT1 inhibitor 5 (compound 16) is a potent URAT1 inhibitor. URAT1 inhibitor 5 can be used in research of hyperuricemia ^[1].

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URAT1 inhibitor 13

Cat. No.: HY-176139

CAS No.: 2816864-54-5

Target:

Research Areas:

URAT1 inhibitor 13 (compound 22k) is a potent URAT1 inhibitor. URAT1 inhibitor 13 can be used in the study of gout ^[1].

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URAT1 inhibitor 3

Cat. No.: HY-151432

CAS No.: 2850331-30-3

Purity: 98.02%

Target:

Research Areas:

URAT1 inhibitor 3 is a potent, orally active, selective URAT1 inhibitor with an IC₅₀ value of 0.8 nM. URAT1 inhibitor 3 has urate-lowering efficacy. URAT1 inhibitor 3 can be used in research of gout and hyperuricemi ^[1].

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URAT1 inhibitor 7

Cat. No.: HY-153970

CAS No.: 1632002-28-8

Target:

Research Areas:

URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC₅₀ of 12 nM. URAT1 inhibitor 7 exhibits microsomal stability (HLM <13 µL/min/mg). URAT1 inhibitor 7 also inhibits CYP2C9, with an IC₅₀ of 4.2 μM. URAT1 inhibitor 7 can be used for gout research ^[1].

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URAT1 inhibitor 1

Cat. No.: HY-114309

CAS No.: 2268720-62-1

Purity: 97.08%

Target:

Research Areas:

URAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC₅₀ of 32 nM. URAT1 inhibitor 1 has potential to treat hyperuricemia associated with gout ^[1].

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URAT1 inhibitor 6

Cat. No.: HY-153969

CAS No.: 2244807-49-4

Target:

Research Areas:

URAT1 inhibitor 6 (Compound 1h) is a potent URAT1 inhibitor (IC₅₀: 35 nM for hURAT1). URAT1 inhibitor 6 is 200- and 8-fold more potent than parent Lesinurad (HY-15258) and Benzbromarone (HY-B1135). URAT1 inhibitor 6 can be used for research of inflammation ^[1].

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URAT1 inhibitor 9

Cat. No.: HY-160265

CAS No.: 2251727-90-7

Target:

Research Areas:

URAT1 inhibitor 9 (Compound 24) is an URAT1 inhibitor that can be used in the study of gout or hyperuricemia ^[1].

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URAT1 inhibitor 2

Cat. No.: HY-143906

CAS No.: 2803951-18-8

Target:

Research Areas:

URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC₅₀ values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated ¹⁴C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout ^[1].

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URAT1 inhibitor 4

Cat. No.: HY-152033

CAS No.: 2700292-02-8

Target:

URAT1 GLUT

Research Areas:

URAT1 inhibitor 4, a Lesinurad derivative, is a potent and orally active URAT1 inhibitor with an IC₅₀ of 7.56 μM. URAT1 inhibitor 4 has higher in vivo urate-lowering efficacy than Lesinurad (HY-15258) ^[1].

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URAT1 inhibitor 11

Cat. No.: HY-168740

CAS No.: 2416416-13-0

Target:

Research Areas:

URAT1 inhibitor 11 (Compound 7) is a URAT1 inhibitor with an IC₅₀ value of 0.18 μM. URAT1 inhibitor 11 exhibits potent hypouricemic effects in hyperuricemic zebrafish induced by Potassium oxonate (HY-17511) and Xanthine sodium salt (HY-W017389) ^[1].

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URAT1/GLUT9-IN-1

Cat. No.: HY-158056

CAS No.: 2883011-18-3

Target:

GLUT URAT1

Research Areas: