14

14 Cited Publications

Synonyms: YM 087

Target:

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V_1a/V₂ receptor antagonist with K_i values of 0.48 nM and 3.04 nM for vasopressin V_1a receptor and V₂ receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure ^[1] .

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3

SR 49059

3 Cited Publications

Cat. No.: HY-18345

CAS No.: 150375-75-0

Target:

Vasopressin Receptor

Research Areas:

Cardiovascular Disease Endocrinology

SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K_i vaule of 1.4 nM ^[1].

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2

RG7713

2 Cited Publications

Cat. No.: HY-12981

CAS No.: 920022-47-5

Purity: 99.92%

Synonyms: RO5028442

Target:

Vasopressin Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease

RG7713 (RO5028442) is a highly potent, selective and brain-penetrant Vasopressin 1a (V1a) receptor antagonist with K_is of 1 nM (hV1a) and 39 nM (mV1a).

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1

L-371,257

1 Cited Publications

Cat. No.: HY-15010

CAS No.: 162042-44-6

Purity: 99.90%

Target:

Oxytocin Receptor Vasopressin Receptor

Research Areas:

Cardiovascular Disease Endocrinology

L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (K_i=19 nM) and vasopressin V1a receptor (K_i=3.7 nM) ^[1] .

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Selepressin

Cat. No.: HY-105239

CAS No.: 876296-47-8

Purity: 99.34%

Synonyms: FE 202158

Target:

Vasopressin Receptor

Research Areas:

Cardiovascular Disease

Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock ^[1] .

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WAY-151932

Cat. No.: HY-19381

CAS No.: 220460-92-4

Synonyms: VNA-932; WAY-VNA 932

Target:

Vasopressin Receptor

Research Areas:

Metabolic Disease Endocrinology

WAY-151932 is a vasopressin V₂-receptor agonist with IC₅₀ of 80.3 nM and 778 nM in human-V₂ binding and V_1a binding assay.

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Selepressin acetate

Cat. No.: HY-105239A

Purity: 98.77%

Synonyms: FE 202158 acetate

Target:

Vasopressin Receptor

Research Areas:

Cardiovascular Disease

Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

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SRX246

Cat. No.: HY-105685

CAS No.: 512784-93-9

Purity: 99.76%

Target:

Vasopressin Receptor

Research Areas:

Cardiovascular Disease Neurological Disease

SRX246 is a potent, BBB-penetrant, highly selective vasopressin 1a (V1a) receptor antagonist (K_i=0.3 nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible binding at 64 others receptors classes, including 35 G-proteincoupled receptors. SRX246 can be used for treatment of stress-related disorders ^[1].

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Invopressin

Cat. No.: HY-P5535

CAS No.: 1488411-60-4

Synonyms: OCE-205

Target:

Vasopressin Receptor

Research Areas:

Inflammation/Immunology

Invopressin (Compound 42) is a vasopressin V1A receptor partial agonist (EC₅₀: 1.0 nM). Invopressin can be used for research of cirrhosis, including bacterial peritonitis, HRS2 and refractory ascites ^[1].

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