548 Results for "

VEGFR-2

" in MedChemExpress (MCE) Product Catalog:
Products (548)

548 Results for "VEGFR-2" in MCE Product Catalog:

323
Sorafenib
Sorafenib
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323 Publications Verification
Cat. No.: HY-10201
CAS No.: 284461-73-0
Purity:  99.92%
Synonyms: Bay 43-9006
Target:  

Raf VEGFR FLT3 Autophagy Apoptosis STAT Akt MMP Cadherin p38 MAPK ERK MEK PI3K PARP Bcl-2 Family Ephrin Receptor PDGFR

Research Areas:  

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma [2] .
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323
Sorafenib tosylate
Sorafenib tosylate
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323 Publications Verification
Cat. No.: HY-10201A
CAS No.: 475207-59-1
Purity:  99.75%
Synonyms: Bay 43-9006 tosylate
Target:  

Raf VEGFR FLT3 Autophagy Apoptosis STAT Akt MMP Cadherin p38 MAPK ERK MEK PI3K PARP Bcl-2 Family

Research Areas:  

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sorafenib (Bay 43-9006) tosylate is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib tosylate induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib tosylate inhibits tumor growth and metastasis in mouse and rat models. Sorafenib tosylate can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma [2] .
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114
Sunitinib
Sunitinib
0 Images
114 Cited Publications
Cat. No.: HY-10255A
CAS No.: 557795-19-4
Purity:  99.04%
Synonyms: SU 11248
Target:  

VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis

Research Areas:  

Cancer

Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation [2].
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114
Sunitinib Malate
Sunitinib Malate
0 Images
114 Cited Publications
Cat. No.: HY-10255
CAS No.: 341031-54-7
Purity:  99.86%
Synonyms: SU 11248 Malate
Target:  

PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis

Research Areas:  

Infection Inflammation/Immunology Cancer

Sunitinib (SU 11248) Malat is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib Malat, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation [2].
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114
Sunitinib glucuronate
Sunitinib glucuronate
0 Images
114 Cited Publications
Cat. No.: HY-10255C
CAS No.: 1818285-48-1
Synonyms: SU 11248 glucuronate
Target:  

PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis

Research Areas:  

Cancer

Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation [2].
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61
Cabozantinib
Cabozantinib
0 Images
61 Cited Publications
Cat. No.: HY-13016
CAS No.: 849217-68-1
Purity:  99.96%
Synonyms: XL184; BMS-907351
Target:  

VEGFR c-Met/HGFR c-Kit TAM Receptor FLT3 Apoptosis

Research Areas:  

Cancer

Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis [2].
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60
Cabozantinib S-malate
Cabozantinib S-malate
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60 Cited Publications
Cat. No.: HY-12044
CAS No.: 1140909-48-3
Purity:  99.90%
Synonyms: XL184 S-malate; BMS-907351 S-malate
Target:  

VEGFR Apoptosis

Research Areas:  

Cancer

Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
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59
Ponatinib
Ponatinib
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59 Cited Publications
Cat. No.: HY-12047
CAS No.: 943319-70-8
Purity:  99.67%
Synonyms: AP24534
Target:  

Bcr-Abl PDGFR VEGFR FGFR Src Autophagy

Research Areas:  

Neurological Disease Inflammation/Immunology Cancer

Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .
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59
Ponatinib hydrochloride
Ponatinib hydrochloride
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59 Cited Publications
Cat. No.: HY-108766
CAS No.: 1114544-31-8
Purity:  99.76%
Synonyms: AP24534 hydrochloride
Target:  

Bcr-Abl FGFR PDGFR VEGFR Src Autophagy

Research Areas:  

Infection Cancer

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .
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45
Axitinib
Axitinib
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45 Cited Publications
Cat. No.: HY-10065
CAS No.: 319460-85-0
Purity:  99.90%
Synonyms: AG-013736
Target:  

VEGFR PDGFR

Research Areas:  

Cancer

Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.
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40
Tanshinone IIA
Tanshinone IIA
0 Images
40 Cited Publications
Cat. No.: HY-N0135
CAS No.: 568-72-9
Synonyms: Dan Shen ketone
Category:  

Quinones Terpenoids 500 - Internal Server Error | MedChemExpress

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