18 Results for "

VLPs

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "VLPs" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N4118
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline; NSC 32944 free base
Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-N2076
CAS No.: 3738-70-3
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Cephaeline hydrochloride ((-)-Cephaeline (hydrochloride); NSC 32944 (monohydrochloride)) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline hydrochloride induces Ferroptosis by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline hydrochloride inhibits cancer cell proliferation, migration and tumor growth. Cephaeline hydrochloride inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline hydrochloride can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
loading...
    loading...
Cat. No.: HY-122046
CAS No.: 956571-77-0
Purity:  98.87%
Target:  

Endogenous Metabolite

Research Areas:  

Infection

Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds .
loading...
    loading...
Cat. No.: HY-161804
Target:  

PROTACs Dengue Virus

Research Areas:  

Infection

GNF-2-deg is a PROTAC degrader targeting the dengue virus envelope protein (DENV E protein), with a DC50 of 0.83 μM in Huh7.5 cells. GNF-2-deg induces CRBN- and proteasome-dependent proteolysis of intracellular E protein. GNF-2-deg inhibits E protein-mediated membrane fusion and blocks viral particle production. GNF-2-deg reduces viral yield in infected cells and retains activity against E protein βOG pocket mutant virus-like particles (VLP). GNF-2-deg can be used in the research of dengue virus infection, Zika virus infection, Japanese encephalitis, West Nile virus infection and yellow fever .
loading...
    loading...
Cat. No.: HY-157241
Research Areas:  

Others

CEX Cation-exchange resin 1 is an ion exchange chromatography resin based on monodisperse polystyrene/divinylbenzene (PS-DVB). The particle size of CEX Cation-exchange resin 1 is 50μm and the ligand is -CH2CH2CH2SO3-. CEX Cation-exchange resin 1 can be used for the separation and purification of antibodies, VLPs, viruses and proteins .
loading...
    loading...
Cat. No.: HY-P10845
CAS No.: 2423969-43-9
Target:  

HIV

Research Areas:  

Infection

KRL74 is a cyclic peptide inhibitor for interaction between the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein(p6/UEV) with an IC50 of 5.44 μM and a Kd of 11.9 μM. KRL74 inhibits the budding process of HIV from host cells with an IC50 of 2 μM in virus-like particle (VLP) budding assay .
loading...
    loading...
Cat. No.: HY-175421
Research Areas:  

Cancer

ArMan is a co-activator of DC-SIGN (CD209) and TLR7. ArMan can selectively bind to DC-SIGN, promoting receptor-mediated endocytosis of the virus-like particle (VLP) platform, thereby enhancing co-binding with TLR7. ArMan can drive dendritic cell activation, shifting the immune response from humoral immunity to type 1 cellular immunity. ArMan can be used in melanoma research .
loading...
    loading...
Cat. No.: HY-175697
Glycosyltransferase-IN-2 (Compound 20) is a Glycosyltransferase inhibitor. Glycosyltransferase-IN-2 has a broad-spectrum anticoronavirus activity with IC50s of 11.3, 5.5 and ~16.2 μM for MHV, HCoV-NL63 and SARS-CoV-2, respectively. Glycosyltransferase-IN-2 interferes with the coronavirus infectivity, alters viral protein glycosylation with inhibition of interaction with the ACE2 receptor or SC-VLP secretion, and inhibits RNA replication. Glycosyltransferase-IN-2 can be used for coronavirus infections research .
loading...
    loading...
loading...
    loading...
loading...
    loading...
Cat. No.: HY-P701236
Purity:  /
Synonyms: /
Species:  
Virus
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-185061
CAS No.: 139361-84-5
Research Areas:  

Others

HEGA-10 is a mild detergent with a high critical micelle concentration (CMC), which can be used to dissolve and extract proteins (HIV-1 spike protein) from the membranes of virus-like particles (VLPs) .
loading...
    loading...
Cat. No.: HY-P702371
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: MC1R; MC1-R; Melanocortin 1 Receptor; Melanocortin 1 Receptor (Alpha Melanocyte Stimulating Hormone Receptor); MSH-R; Melanotropin Receptor; Melanocyte-Stimulating Hormone Receptor; SHEP2; Alpha Melanocyte Stimulating Hormone Receptor; CMM5; Melanocortin
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-N4118A
CAS No.: 6014-81-9
Synonyms: (-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide
Cephaeline dihydrobromide ((-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline dihydrobromide induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline dihydrobromide inhibits cancer cell proliferation, migration and tumor growth. Cephaeline dihydrobromide inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline dihydrobromide can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
loading...
    loading...
Cat. No.: HY-P702440
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: SLC26A4; Solute Carrier Family 26, Member 4; Prev. DFNB4; Uncharacterized Protein SLC26A4; PDS; Pendred Syndrome; Pendrin; TDH2B; Solute Carrier Family 26 (Anion Exchanger), Member 4; EVA; Sodium-Independent Chloride/Iodide Transporter; Solute Carrier Fam
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P702203
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: ADRA2A; Alpha-2A Adrenoreceptor; Prev. ADRA2R; Alpha-2A Adrenoceptor; Prev. ADRA2; Alpha-2-Adrenergic Receptor, Platelet Type; ADRAR; Alpha-2A-Adrenergic Receptor; Alpha-2 Adrenergic Receptor Subtype C10; Alpha-2AAR; Adrenergic, Alpha-2A-, Receptor; ALPHA
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P702323
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: HRH3; Histamine H3 Receptor Isoform 6; Histamine Receptor H3; Histamine H3 Receptor Isoform 5; GPCR97; Histamine H3 Receptor Isoform 3; Histamine H3 Receptor; G Protein-Coupled Receptor 97; HH3R; G-Protein Coupled Receptor 97; H3R
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P702322
Purity:  Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: HRH3; Histamine H3 Receptor Isoform 6; Histamine Receptor H3; Histamine H3 Receptor Isoform 5; GPCR97; Histamine H3 Receptor Isoform 3; Histamine H3 Receptor; G Protein-Coupled Receptor 97; HH3R; G-Protein Coupled Receptor 97; H3R
Species:  
Human
Source:  
HEK293
loading...
    loading...
  • 1