7 Results for "

Val-Ala dipeptide

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "Val-Ala dipeptide" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-W007035
CAS No.: 27493-61-4
Synonyms: Valyl-Alanine
H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .
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Cat. No.: HY-164729
FZ-AD005 is a DLL3-targeting antibody-drug conjugate (ADC) with high selectivity, composed of the anti-DLL3 antibody FZ-A038 (HY-P990896), a dipeptide linker (Val-Ala), and DXd (HY-13631D). The Kd value of FZ-AD005 for human DLL3 ranges from 13.29 to 58.3 pmol/L. After binding to DLL3 on the cell surface, FZ-AD005 mediates endocytosis, and the payload DXd is released via cleavage by lysosomal cathepsins. DXd inhibits topoisomerase TopI to induce double-strand DNA breaks, cell cycle arrest and apoptosis, and FZ-AD005 exhibits bystander killing activity against adjacent DLL3-negative cells. FZ-AD005 shows stable circulation in vivo, has good tolerance and acceptable pharmacokinetic profiles in rats and cynomolgus monkeys, and effectively inhibits the growth of DLL3-expressing tumor cells. FZ-AD005 serves as a promising candidate molecule for research on small cell lung cancer and human neuroendocrine prostate cancer .
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Cat. No.: HY-42709
CAS No.: 24787-89-1
Synonyms: Carbobenzoxy-L-Valyl-L-Alanine
Research Areas:  

Cancer

Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development[1] .
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Cat. No.: HY-P4658
CAS No.: 87810-63-7
Target:  

Dipeptidyl Peptidase

Research Areas:  

Others

H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .
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Cat. No.: HY-W007035R
CAS No.: 27493-61-4
Synonyms: Valyl-Alanine (Standard)
H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .
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Cat. No.: HY-W007035S
Synonyms: Valyl-Alanine-13C5,15N TFA
H-Val-Ala-OH- 13C5, 15N (Valyl-alanine- 13C5, 15N) TFA is the 13C- and 15N-labeled H-Val-Ala-OH (HY-W007035). H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .
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Cat. No.: HY-184906
Research Areas:  

Cancer

Mal-PEG4-Val-Ala-Ph-2,2-dimethylpropanoic acid is a maleimide-functionalized PEG4-Val-Ala dipeptide linker bearing a trimethyl-locked adapter for exatecan conjugation, which enables thiol conjugation via the maleimide group and facilitates payload release. Mal-PEG4-Val-Ala-Ph-2,2-dimethylpropanoic acid is used in cancer research .
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