136 Results for "

Vasoconstriction

" in MedChemExpress (MCE) Product Catalog:
Products (136)

136 Results for "Vasoconstriction" in MCE Product Catalog:

14
Conivaptan hydrochloride
Conivaptan hydrochloride
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14 Publications Verification
Cat. No.: HY-18347A
CAS No.: 168626-94-6
Synonyms: YM 087
Target:  

Vasopressin Receptor Cytochrome P450

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure .
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4
Xanthone
Xanthone
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4 Cited Publications
Cat. No.: HY-N0126
CAS No.: 90-47-1
Category:  

Infection Xanthones Guttiferae Extract 500 - Internal Server Error | MedChemExpress

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