33

33 Publications Verification

Synonyms: EPA; Timnodonic acid

Category:

Human Gut Microbiota Metabolites Neurological Disease Ketones, Aldehydes, Acids Marine natural products Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite Histone Demethylase

Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

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33

Eicosapentaenoic Acid sodium

33 Publications Verification

Cat. No.: HY-W011269

CAS No.: 73167-03-0

Synonyms: EPA sodium; Timnodonic acid sodium

Category:

Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Histone Demethylase

Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .

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22

Prostaglandin E1

22 Cited Publications

Cat. No.: HY-B0131

CAS No.: 745-65-3

Synonyms: Alprostadil; PGE1

Category:

Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:

Prostaglandin Receptor Endogenous Metabolite

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

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19

Talfirastide acetate

19 Cited Publications

Cat. No.: HY-12403A

CAS No.: 2855063-75-9

Purity: 99.87%

Synonyms: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology

Target:

Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

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19

Talfirastide

19 Cited Publications

Cat. No.: HY-12403

CAS No.: 51833-78-4

Purity: 99.75%

Synonyms: TXA127; Angiotensin (1-7); Ang-(1-7)

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Angiotensin Receptor Angiotensin-converting Enzyme (ACE)

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

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11

Minoxidil

11 Cited Publications

Cat. No.: HY-B0112

CAS No.: 38304-91-5

Synonyms: U10858

Category:

Cardiovascular Disease Disease Research Fields Cancer

Target:

Potassium Channel

Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

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7

Doxepin Hydrochloride

7 Cited Publications

Cat. No.: HY-B0725

CAS No.: 1229-29-4

Target:

Akt mTOR Drug Intermediate

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

Doxepin Hydrochloride is an orally active, blood-brain barrier penetrant tricyclic antidepressant with multiple activities including hypnosis, sedation, analgesia and vasodilation. Doxepin Hydrochloride enhances the expression of PSD-95 and synapsin 1 via the PI3K/AKT/mTOR signaling pathway, and is metabolized to DesmethylDoxepin Hydrochloride in vivo. Doxepin Hydrochloride can be used in research related to various diseases such as depression, anxiety, obesity and atopic dermatitis .

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7

Doxepin

7 Cited Publications

Cat. No.: HY-B0725A

CAS No.: 1668-19-5

Target:

Akt mTOR Drug Intermediate

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

Doxepin is an orally active, blood-brain barrier penetrant tricyclic antidepressant with multiple activities including hypnosis, sedation, analgesia and vasodilation. Doxepin enhances the expression of PSD-95 and synapsin 1 via the PI3K/AKT/mTOR signaling pathway, and is metabolized to Desmethyldoxepin in vivo. Doxepin can be used in research related to various diseases such as depression, anxiety, obesity and atopic dermatitis .

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7

Buloxibutid

7 Cited Publications

Cat. No.: HY-100113

CAS No.: 477775-14-7

Purity: 99.02%

Synonyms: AT2 receptor agonist C21

Target:

Angiotensin Receptor p38 MAPK TGF-beta/Smad TGF-β Receptor MMP

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Buloxibutid (AT2 receptor agonist C21) is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a K_i value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis .

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6

RN-1747

6 Cited Publications

Cat. No.: HY-19976

CAS No.: 1024448-59-6

Target:

TRP Channel

Research Areas:

Cardiovascular Disease Metabolic Disease

RN-1747 is a selective TRPV4 channel agonist, with EC₅₀ values of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 acts as an antagonist of TRPM8, with an IC₅₀ of 4 μM. Topical cutaneous administration of RN-1747 induces hypothermia, increases tail heat loss via cutaneous vasodilation, and promotes cold-seeking behavior in rats. Intracerebroventricular administration of RN-1747 does not induce hypothermia in rats .

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4

LDN-27219

4 Cited Publications

Cat. No.: HY-16693

CAS No.: 312946-37-5

Target:

Glutaminase

Research Areas:

Cardiovascular Disease Others

LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC₅₀ value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease .

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4

(±)-Naringenin

4 Cited Publications

Cat. No.: HY-W011641

CAS No.: 67604-48-2

Category:

Cardiovascular Disease Flavonoids Flavonones Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase

(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

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