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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
YFV 17D
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "YFV 17D" in MCE Product Catalog:
2
Research Areas:
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication. .
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1 Cited Publications
Cat. No.: HY-W008662
CAS No.: 146954-74-7
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2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity .
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1 Cited Publications
Cat. No.: HY-P1159A
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2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ( [HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) .
Synonyms: IDX21437; MK-3682
Uprifosbuvir (IDX21437; MK-3682) is a nucleotide analog inhibitor that inhibits YFV NS5 RNA-dependent RNA polymerase (RNA polymerase) and HCV NS5b. Uprifosbuvir can be used for research on yellow fever and chronic hepatitis C virus (HCV) infection .
Cat. No.: HY-B0649S
CAS No.: 1261393-54-7
Cat. No.: HY-N1446S3
CAS No.: 223487-44-3
Synonyms: 9-cis-Octadecenoic acid-d17; 9Z-Octadecenoic acid-d17
Cat. No.: HY-N1131S
CAS No.: 52168-48-6
Synonyms: 2,2,6,6-Tetramethyl-4-piperidone-d17
Cat. No.: HY-N7057S
CAS No.: 130348-94-6
Synonyms: Pelargonic acid-d17
Cat. No.: HY-P1159
CAS No.: 102805-45-8
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Cat. No.: HY-183730
CAS No.: 2841473-92-3
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4E1RCat 17d is a derivative of the ATG5 inhibitor lead compound T1742 (HY-183807). 4E1RCat 17d shows no activity against the interactions of ATG5-ATG16L1 and ATG5-TECAIR. 4E1RCat 17d induces Autophagy inhibition .
Cat. No.: HY-RS06700
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IL17D Human Pre-designed siRNA Set A contains three designed siRNAs for IL17D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-150549
CAS No.: 2892016-32-7
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HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus .
Cat. No.: HY-157023
CAS No.: 2952530-26-4
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RCB16007 is a Yellow Fever Virus (YFV) Inhibitor. RCB16007 inhibits the West Nile virus (EC50: 7.9 μM, CC50: 17 μM) .
Cat. No.: HY-W008954S
CAS No.: 1259188-37-8
Synonyms: 'TRIOCTYL' PHOSPHATE-d17
Cat. No.: HY-172919
CAS No.: 2976498-55-0
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PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD +), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer .
Cat. No.: HY-100561S
CAS No.: 90429-66-6
Synonyms: 4-Hydroxy-TEMPO-d17,15N; MBM-02-d17,15N
Research Areas:
Tempol-d17, 15N is the deuterium labeled Tempol . Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS) .
Cat. No.: HY-172836S
CAS No.: 3074098-20-4
Cat. No.: HY-157326
CAS No.: 2764830-43-3
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hMAO-B-IN-6 (compound 17d) is a potent and selective inhibitor of hMAO-B with an IC50 of 67.02 nM. hMAO-B-IN-6 significantly improves Scopolamine (HY-N0296)-induced cognitive impairment in AD mice .
Cat. No.: HY-155739
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ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist (IC50=0.26 nM), which can be used for research in pulmonary arterial hypertension (PAH). ET receptor antagonist 3 attenuates monocrotaline (HY-N0750) induced PAH in rat model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
