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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
YK-012
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "YK-012" in MCE Product Catalog:
Cat. No.: HY-P992528
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YK012 is an anti-CD19 and CD3 T cell engager with a Kd of 1.96 μM for hCD3 ε/δ and a Kd of approximately 0.5 nM for hCD19. YK012 binds CD3/TCR and activates cells only upon crosslinking by CD19-positive target cells. YK012 induces cytokine release (IL-2, TNF-α, IFN-γ, IL-6) as well as granzyme B/perforin release. YK012 alleviates pathological symptoms in a collagen-induced arthritis model. YK012 exhibits extremely low antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activity, and does not mediate killing of CD19-negative cells. YK012 can be used for research on rheumatoid arthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
