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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
ZER1
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "ZER1" in MCE Product Catalog:
Cat. No.: HY-RS16027
Target:
Research Areas:
ZER1 Human Pre-designed siRNA Set A contains three designed siRNAs for ZER1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS22362
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Zer1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Zer1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-185879
CAS No.: 3132618-63-1
Target:
ZER1 binder-2 is a ZER1 E3 ubiquitin ligase binder with an EC50 value of 51.04 nM. ZER1 binder-2 is applicable to the research of cancers induced by HPV infection [1].
Cat. No.: HY-185880
CAS No.: 3132617-69-4
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ZER1 binder-3 is an E3 ubiquitin ligase ZER1-binding pyridazinone derivative with an FP EC50 value of 56.61 nM. ZER1 binder-3 can be used for the research of cancers arising from infection by human papillomavirus (HPV) [1].
Cat. No.: HY-185878
CAS No.: 3132618-21-1
Target:
ZER1 binder-1 is a pyridazinone derivative and a binding agent for the E3 ubiquitin ligase ZER1, with an FP EC50 value of 55.59 nM. ZER1 binder-1 is applicable to the research of cancers induced by human papillomavirus (HPV) infection [1].
Cat. No.: HY-RS28886
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Research Areas:
Zer1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Zer1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-189230
CAS No.: 3108114-67-3
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Research Areas:
NEP48 is a small-molecule antagonist targeting the ZER1 (E3 ubiquitin ligase)-E7 oncogenic axis. NEP48 binds to the MHGD/N-degron binding pocket within the ARM repeat domain of ZER1, competitively blocking E7-ZER1 binding and ZER1-mediated substrate degradation. NEP48 disrupts the ZER1-E7 interaction, leading to Rb stabilization and silencing of E2F-driven transcriptional programs. NEP48 inhibits the proliferation of HPV-positive cancer cells and can be used for research on HPV-positive cervical cancer [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
