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18 Results for "

Zymosan

" in MedChemExpress (MCE) Product Catalog:

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Zymosan A

2 Cited Publications

Cat. No.: HY-W250113

CAS No.: 58856-93-2

Synonyms: Zymosan A from Saccharomyces cerevisiae

Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury .

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JNJ-7777120

1 Cited Publications

Cat. No.: HY-13508

CAS No.: 459168-41-3

Purity: 99.95%

Target:

Histamine Receptor

Research Areas:

Inflammation/Immunology

JNJ-7777120 is a potent and selective histamine H₄ receptor antagonist (K_i=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory .

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Zymosan (ZM), 95%

Cat. No.: HY-159069

CAS No.: 9010-72-4

Purity: 95.02%

Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .

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PROTAC BTK Degrader-6

Cat. No.: HY-149391

CAS No.: 2767204-39-5

Target:

PROTACs Btk NF-κB Interleukin Related

Research Areas:

Inflammation/Immunology

PROTAC BTK Degrader-6 is an orally active PROTAC-based BTK degrader with a DC₅₀ of 3.18 nM. PROTAC BTK Degrader-6 induces BTK degradation via proteasomal degradation, ubiquitination, and CRBN ligase recruitment pathways. PROTAC BTK Degrader-6 inhibits NF-κB activation, mRNA expression of IL-1β and IL-6, as well as the secretion of pro-inflammatory cytokines. PROTAC BTK Degrader-6 reduces inflammatory responses in a zymosan-induced mouse model of peritonitis. PROTAC BTK Degrader-6 can be used in peritonitis-related research .

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