25

AB-680

25 Publications Verification

Cat. No.: HY-125286

CAS No.: 2105904-82-1

Purity: 99.71%

Target:

CD73

Research Areas:

Cancer

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a K_i of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity .

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22

JR-AB2-011

22 Cited Publications

Cat. No.: HY-122022

CAS No.: 2411853-34-2

Purity: 98.15%

Target:

mTOR

Research Areas:

Cancer

JR-AB2-011 is a selective mTORC2 inhibitor with an IC₅₀ value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (K_i: 0.19 μM) ^[1].JR-AB2-011 decreases the phosphorylation level of Akt, decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death .

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10

AT9283

10 Cited Publications

Cat. No.: HY-50514

CAS No.: 896466-04-9

Target:

JAK Aurora Kinase Bcr-Abl FLT3 Apoptosis Autophagy

Research Areas:

Cancer

AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC₅₀s ranging from 1 to 30 nM). AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo .

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10

IFN-alpha 2a/IFNA2 Protein, Human (R46K)

10 Cited Publications

Cat. No.: HY-P7022

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNA2; IFN-Alpha-2; Interferon Alpha 2; IFNA2B; IFN-AlphaA; LeIF A; IFNA; Interferon Alpha 2a; Alpha-2a Interferon; Interferon Alpha-A; Interferon Alpha 2b; Interferon 1AB4; Interferon Alpha A; IFNA2C; Interferon Alpha-2; IFNA2A

Species:

Human

Source:

E. coli

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9

Etrumadenant

9 Cited Publications

Cat. No.: HY-129393

CAS No.: 2239273-34-6

Purity: 99.67%

Synonyms: AB928

Target:

Adenosine Receptor

Research Areas:

Inflammation/Immunology Cancer

Etrumadenant (AB928) is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. Etrumadenant relieves adenosine-mediated immune suppression. Etrumadenant has immunomodulatory and antitumor activities .

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8

IFN-alpha 2b/IFNA2 Protein, Human

8 Cited Publications

Cat. No.: HY-P7023

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNA2; IFN-Alpha-2; Interferon Alpha 2; IFNA2B; IFN-AlphaA; LeIF A; IFNA; Interferon Alpha 2a; Alpha-2a Interferon; Interferon Alpha-A; Interferon Alpha 2b; Interferon 1AB4; Interferon Alpha A; IFNA2C; Interferon Alpha-2; IFNA2A

Species:

Human

Source:

E. coli

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7

Methoxy-X04

7 Cited Publications

Cat. No.: HY-103240

CAS No.: 863918-78-9

Purity: 98.47%

Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (K_i= 26.8 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity .

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5

Masitinib

5 Cited Publications

Cat. No.: HY-10209

CAS No.: 790299-79-5

Purity: 99.95%

Synonyms: AB1010

Target:

c-Kit PDGFR Src FGFR FAK Apoptosis

Research Areas:

Cancer

Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity .

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5

Masitinib mesylate

5 Cited Publications

Cat. No.: HY-10209A

CAS No.: 1048007-93-7

Purity: 99.51%

Synonyms: AB-1010 mesylate

Target:

c-Kit PDGFR Src FGFR Apoptosis

Research Areas:

Cancer

Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity .

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5

Tropisetron Hydrochloride

5 Cited Publications

Cat. No.: HY-B0020

CAS No.: 105826-92-4

Synonyms: SDZ-ICS-930

Target:

5-HT Receptor nAChR

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC₅₀ of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation .

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3

Taletrectinib

3 Cited Publications

Cat. No.: HY-131003

CAS No.: 1505515-69-4

Purity: 99.78%

Synonyms: DS-6051b; AB-106; IBI-344

Target:

ROS Kinase

Research Areas:

Cancer

Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC₅₀s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants .

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3

AB-423

3 Cited Publications

Cat. No.: HY-112142

CAS No.: 1572510-80-5

Purity: 99.31%

Synonyms: (R)-DVR-23

Target:

HBV

Research Areas:

Infection

AB-423 is an inhibitor of HBV capsid assembly, and potent inhibits HBV replication with EC₅₀/EC₉₀ of 0.08-0.27 μM/0.33-1.32 μM in cells.

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3

GSK2801

3 Cited Publications

Cat. No.: HY-15658

CAS No.: 1619994-68-1

Purity: 99.95%

Target:

Epigenetic Reader Domain Apoptosis

Research Areas:

Cancer

GSK2801, a chemical probe, is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with K_d values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4 .

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2

Safusidenib

2 Cited Publications

Cat. No.: HY-145594

CAS No.: 1898206-17-1

Synonyms: AB-291; DS-1001

Target:

Isocitrate Dehydrogenase (IDH)

Research Areas:

Cancer

Safusidenib (AB-291; DS-1001) is an orally bioavailable, selective mutant IDH1 inhibitor. Safusidenib strongly inhibits mutant IDH1 but not wild-type IDH1. Safusidenib impairs tumor activity in chondrosarcoma . Safusidenib exhibits activity against IDH1R132H, and IDH1R132C with IC₅₀s of 15, and 130 nM in assays without any preincubation, respectively .

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2

BAZ2-ICR

2 Cited Publications

Cat. No.: HY-19336

CAS No.: 1665195-94-7

Target:

Epigenetic Reader Domain

Research Areas:

Cancer

BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC₅₀s of 130 nM and 180 nM, and K_ds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe .

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2

AK-2292

2 Cited Publications

Cat. No.: HY-148813

CAS No.: 2984506-77-4

Purity: 99.73%

Target:

PROTACs STAT

Research Areas:

Cancer

AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC₅₀ of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models . AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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2

Animal-Free Activin A Protein, Human/Mouse/Rat (His)

2 Cited Publications

Cat. No.: HY-P700159AF

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; Erythroid Differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype

Species:

Human Rat Mouse

Source:

E. coli

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2

IFN-alpha 2/IFNA2 Protein, Mouse

2 Cited Publications

Cat. No.: HY-P7544

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: IFNA2; IFN-Alpha-2; Interferon Alpha 2; IFNA2B; IFN-AlphaA; LeIF A; IFNA; Interferon Alpha 2a; Alpha-2a Interferon; Interferon Alpha-A; Interferon Alpha 2b; Interferon 1AB4; Interferon Alpha A; IFNA2C; Interferon Alpha-2; IFNA2A

Species:

Mouse

Source:

E. coli

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