13

Alvelestat

13 Cited Publications

Cat. No.: HY-15651

CAS No.: 848141-11-7

Purity: 99.87%

Synonyms: AZD9668

Target:

Elastase Claudin Interleukin Related MMP

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .

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6

IAXO-102

6 Cited Publications

Cat. No.: HY-125171

CAS No.: 1115270-63-7

Purity: ≥98.0%

Target:

Toll-like Receptor (TLR)

Research Areas:

Inflammation/Immunology

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .

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4

Calcium chloride anhydrous, for cell culture

4 Cited Publications

Cat. No.: HY-Y0406E

CAS No.: 10043-52-4

Synonyms: Calcium dichloride anhydrous, for cell culture

Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers . Calcium chloride anhydrous, for cell culture can be used for animal modeling, to construct abdominal aortic aneurysm models .

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3

Bromopride

3 Cited Publications

Cat. No.: HY-B1164

CAS No.: 4093-35-0

Target:

Dopamine Receptor

Research Areas:

Neurological Disease

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting) .

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2

Tamsulosin

2 Cited Publications

Cat. No.: HY-B0661

CAS No.: 106133-20-4

Synonyms: (R)-(-)-YM12617 free base; LY253351 free base

Target:

Adrenergic Receptor Apoptosis

Research Areas:

Neurological Disease Endocrinology Cancer

Tamsulosin ((R)-(-)-YM12617 free base) is an orally active antagonist of α₁-adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .

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2

Tamsulosin hydrochloride

2 Cited Publications

Cat. No.: HY-B0661A

CAS No.: 106463-17-6

Synonyms: (R)-(-)-YM12617; LY253351

Category:

Neurological Disease Disease Research Fields Endocrinology

Target:

Adrenergic Receptor Apoptosis

Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α₁-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models .

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2

Sulopenem

2 Cited Publications

Cat. No.: HY-105284

CAS No.: 120788-07-0

Purity: 99.70%

Synonyms: CP-70429

Target:

Beta-lactamase Bacterial Antibiotic

Research Areas:

Infection

Sulopenem (CP-70429) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia .

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2

Levamlodipine besylate

2 Cited Publications

Cat. No.: HY-14744A

CAS No.: 150566-71-5

Purity: 99.84%

Synonyms: (S)-Amlodipine besylate; Levoamlodipine besylate

Target:

Calcium Channel MMP

Research Areas:

Cardiovascular Disease

Levamlodipine ((S)-Amlodipine; Levoamlodipin) besylate is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine besylate significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine besylate not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine besylate exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine besylate may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine besylate can be used in research related to hypertension and atherosclerosis .

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2

ASP7663

2 Cited Publications

Cat. No.: HY-101907

CAS No.: 1190217-35-6

Purity: 99.16%

Target:

TRP Channel

Research Areas:

Neurological Disease

ASP7663 is an orally active and selective TRPA1 agonist. ASP7663 exerts both anti-constipation and anti-abdominal pain actions .

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2

Levamlodipine

2 Cited Publications

Cat. No.: HY-14744

CAS No.: 103129-82-4

Purity: 98.53%

Synonyms: (S)-Amlodipine; Levoamlodipine

Target:

Calcium Channel MMP

Research Areas:

Cardiovascular Disease Neurological Disease

Levamlodipine ((S)-Amlodipine; Levoamlodipin) is an orally active L-type calcium channel blocker and MMP-9 modulator with high permeability and retention properties. Levamlodipine significantly enhances plaque stability and improves lipid profiles by reducing blood pressure, decreasing systolic blood pressure variability, and inhibiting MMP-9 expression in atherosclerotic plaques. Levamlodipine not only alleviates cardiac and aortic hypertrophy and prevents renal atrophy, but also produces synergistic effects in blood pressure reduction and organ protection when combined with bisoprolol (HY-129029). Levamlodipine exerts no significant inhibitory effect on abdominal aortic intimal hyperplasia. When excessively accumulated in the epidermis, Levamlodipine may induce changes in keratin structure, impair the skin barrier and trigger inflammation; long-term use further exacerbates skin irritation caused by local administration. Levamlodipine can be used in research related to hypertension and atherosclerosis .

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