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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
703 Results for "
abnormal mitotic figures
" in MedChemExpress (MCE) Product Catalog:
Products (703)
703 Results for "abnormal mitotic figures" in MCE Product Catalog:
414
414 Publications Verification
Cat. No.: HY-B0015
CAS No.: 33069-62-4
305
Target:
Research Areas:
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .
183
183
Research Areas:
Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .
101
101 Cited Publications
Synonyms: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
Research Areas:
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
82
Target:
Research Areas:
Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity .
63
63 Cited Publications
Synonyms: MMAE; SGD-1010
Target:
Research Areas:
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
40
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Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis. Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models .
40
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Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models .
31
31 Cited Publications
Category:
Alkaloids Neurological Disease Anti-aging Animal Pyridine Alkaloids Metabolic Disease Disease Research Fields
Target:
31
31 Cited Publications
Cat. No.: HY-123033B
CAS No.: 2415657-86-0
Category:
Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
31
31 Cited Publications
Category:
Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
25
Category:
Alkaloids Plant Pyrrole Alkaloids Lycoris radiata (L’Her.) Herb. Extract Amaryllidaceae Extract Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Cancer
Target:
24
24 Cited Publications
Synonyms: KW-2307; Nor-5'-anhydrovinblastine ditartrate
Category:
Alkaloids Plant Catharanthus roseus (L.) G. Don Extract Disease Research Fields Cancer Alkaloid Dimers Apocynaceae Extract
Target:
17
17 Cited Publications
Cat. No.: HY-N6733
CAS No.: 38966-21-1
12
12 Cited Publications
Synonyms: (±)-Monastrol
Research Areas:
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
11
11 Cited Publications
Synonyms: Monomethyl auristatin E-d8; Deuterated labeled MMAE
11
11 Cited Publications
Synonyms: GTP trisodium salt hydrate
11
8
8 Cited Publications
Synonyms: Vanillylacetone; Gingerone
Category:
Plant Monophenols Zingiberaceae Extract Ketones, Aldehydes, Acids Metabolic Disease Phenols Zingiber officinale Roscoe Extract Disease Research Fields Inflammation/Immunology
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
