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86 Results for "

abundance

" in MedChemExpress (MCE) Product Catalog:

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3BDO

21 Publications Verification

Cat. No.: HY-U00434

CAS No.: 890405-51-3

Target:

mTOR Autophagy Apoptosis

Research Areas:

Infection Inflammation/Immunology

3BDO is a IFITM3 modulator and mTOR activator with antiviral and autophagy-inhibiting effects. 3BDO exhibits inhibitory activity against porcine coronaviruses. 3BDO increases the protein abundance of IFITM3, inhibits virus-cell membrane fusion, and blocks viral entry. 3BDO inhibits the entry of transmissible gastroenteritis virus, porcine epidemic diarrhea virus, and porcine respiratory coronavirus into host cells. 3BDO can be used for research on porcine coronavirus infection .

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August 31

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Tomivosertib

18 Cited Publications

Cat. No.: HY-100022

CAS No.: 1849590-01-7

Purity: 99.92%

Synonyms: eFT508

Target:

MNK PD-1/PD-L1

Research Areas:

Cancer

Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC₅₀s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC₅₀=2-16 nM) in tumor cell lines . Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance .

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