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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
420 Results for "
acetaminophen exposure
" in MedChemExpress (MCE) Product Catalog:
Products (420)
420 Results for "acetaminophen exposure" in MCE Product Catalog:
82
78
78 Cited Publications
Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
32
32 Cited Publications
Research Areas:
IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway .
32
32 Cited Publications
Research Areas:
IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway .
7
7 Cited Publications
Cat. No.: HY-D1063
CAS No.: 207399-07-3
4
4 Cited Publications
Cat. No.: HY-P2336A
Target:
Research Areas:
3
3
3 Cited Publications
Cat. No.: HY-16100
CAS No.: 1291779-76-4
Target:
Research Areas:
BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats .
3
Category:
Quinones Plant Other Diseases Other Families Extract Disease Research Fields Naphthalene Quinones Alkanna cappadocica Extract
Target:
3
3 Cited Publications
Cat. No.: HY-A0183
CAS No.: 1446756-47-3
Synonyms: Phospholipids, phosphatidylserines; Serine glycerophosphatides
Category:
Target:
3
3 Cited Publications
Synonyms: (-)-Cotinine; (S)-Cotinine; NIH-10498
Category:
Alkaloids Plant Pyrrole Alkaloids Other Diseases Pyridine Alkaloids Nicotiana tabacum L. Extract Endogenous metabolite Disease Research Fields Solanaceae Extract
Target:
3
2
2 Cited Publications
Cat. No.: HY-B1444
CAS No.: 24168-96-5
Target:
Research Areas:
Isoconazole nitrate is a broad-spectrum antimicrobial agent with a highly effective antimycotic and gram-positive antibacterial activity, exhibiting a rapid rate of absorption and low systemic exposure potential .
2
2 Cited Publications
Synonyms: APAP-Cys TFA
Target:
Research Areas:
Paracetamol-cysteine TFA (APAP-Cys TFA) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) .
2
2 Cited Publications
Target:
2
Category:
Alkaloids Plant Neurological Disease Other Alkaloids Disease Research Fields Endocrinology Datura stramonium L. Extract Solanaceae Extract
Target:
2
2 Cited Publications
Cat. No.: HY-B0459A
CAS No.: 85700-55-6
Synonyms: 6,7-Epoxytropine hydrochloride
Target:
Research Areas:
Scopine hydrochloride is a metabolite of Scopolamine (HY-N0296) and brain-targeting compound. Scopine hydrochloride significantly increases the brain exposure of Chlorambucil (HY-13593) and enhances its anti-glioma activity. Scopine hydrochloride can be used in targeted therapy research for brain gliomas .
2
2 Cited Publications
Cat. No.: HY-W011689
CAS No.: 793-24-8
Target:
Research Areas:
6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos .
2
2 Cited Publications
Target:
Free Radical Scavengers TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species (ROS)
Research Areas:
NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .
2
Target:
Environmental Pollutants Biochemical Assay Reagents Interleukin Related NO Synthase Aminotransferases (Transaminases) NF-κB
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
