952

Bafilomycin A1

952 Publications Verification

Cat. No.: HY-100558

CAS No.: 88899-55-2

Purity: 99.95%

Synonyms: BafA1

Category:

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Anticancer Disease Research Fields

Target:

Proton Pump Autophagy Antibiotic Bacterial Apoptosis

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H ⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .

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43

Liraglutide

43 Cited Publications

Cat. No.: HY-P0014

CAS No.: 204656-20-2

Target:

GCGR GLP Receptor

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

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43

Liraglutide TFA

43 Cited Publications

Cat. No.: HY-P0014B

Target:

GLP Receptor

Research Areas:

Metabolic Disease

Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). Liraglutide (TFA) can activate GLP-1, leading to the release of insulin in the presence of increased glucose concentration. Liraglutide (TFA) also reduces glucagon secretion in a glucose-dependent manner. Liraglutide (TFA) can be studied in research on type 2 diabetes .

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30

Concanamycin A

30 Cited Publications

Cat. No.: HY-N1724

CAS No.: 80890-47-7

Synonyms: Antibiotic X 4357B; Folimycin; X 4357B

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Proton Pump Bacterial Antibiotic

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

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30

Concanamycin A (purity≥70%)

30 Cited Publications

Cat. No.: HY-N1724A

CAS No.: 80890-47-7

Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)

Category:

Microorganisms Antibiotics

Target:

Proton Pump Bacterial Antibiotic

Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

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11

ML-SA1

11 Cited Publications

Cat. No.: HY-108462

CAS No.: 332382-54-4

Purity: 99.44%

Target:

Dengue Virus TRP Channel Flavivirus

Research Areas:

Infection

ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC₅₀ value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .

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6

EN6

6 Cited Publications

Cat. No.: HY-128892

CAS No.: 1808714-73-9

Purity: 99.42%

Target:

Autophagy

Research Areas:

Neurological Disease

EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .

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4

Cagrilintide

4 Cited Publications

Cat. No.: HY-P3462

CAS No.: 1415456-99-3

Target:

CGRP Receptor

Research Areas:

Metabolic Disease

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .

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4

Cagrilintide acetate

4 Cited Publications

Cat. No.: HY-P3462A

Target:

CGRP Receptor

Research Areas:

Metabolic Disease

Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .

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