12

12 Publications Verification

Category:

Anti-aging Endocrine diseases Amino acids Endogenous metabolite Research on Agricultural Breeding Agricultural Research Microorganisms Other Diseases Disease markers Nervous System Disorder Disease Research Fields Cardiovascular System Disorder

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis Keap1-Nrf2

L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity .

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7

Citraconic acid

7 Cited Publications

Cat. No.: HY-113298

CAS No.: 498-23-7

Purity: 98.73%

Synonyms: Methylmaleic acid; Citraconate

Category:

Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS)

Citraconic acid (Methylmaleic acid) is an orally active inhibitor targeting the NLRP3 inflammasome and Keap1-Nrf2 pathway. Citraconic acid reduces reactive oxygen species (ROS) generation by inhibiting succinate dehydrogenase (SDH) activity. Citraconic acid also modifies the conformation of Keap1 protein, relieves its inhibition of Nrf2, promotes antioxidant gene expression, and inhibits NLRP3 activation and the release of pro-inflammatory factors such as IL-1β and IL-18. Citraconic acid has anti-inflammatory and antioxidant activities, can reduce oxidative stress and cell pyroptosis, improve tissue damage, and can be used for the research of inflammation-related diseases such as acute renal ischemia-reperfusion injury. Citraconic acid is an isomer of Itaconic acid (HY-Y052) .

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5

D-Ribose(mixture of isomers)

5 Cited Publications

Cat. No.: HY-W018772

CAS No.: 50-69-1

Category:

Microorganisms Endogenous metabolite Disease Research Fields Saccharides Cancer

Target:

Endogenous Metabolite

D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

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5

2BAct

5 Cited Publications

Cat. No.: HY-125021

CAS No.: 2143542-28-1

Purity: 99.31%

Target:

Eukaryotic Initiation Factor (eIF)

Research Areas:

Neurological Disease

2BAct is a highly selective, orally active, and CNS-penetrant eIF2B (eukaryotic initiation factor 2B) activator with an EC₅₀ of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .

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3

L-Pyroglutamic acid

3 Cited Publications

Cat. No.: HY-76082

CAS No.: 98-79-3

Category:

Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Cardiovascular System Disorder

Target:

Endogenous Metabolite

L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid can be used as a biomarker for systemic lupus erythematosus (SLE) .

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3

Endoxifen (Z-isomer)

3 Cited Publications

Cat. No.: HY-18719

CAS No.: 112093-28-4

Target:

PKC Estrogen Receptor/ERR PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Cancer

Endoxifen Z-isomer is an orally active selective PKCβ1 inhibitor with an IC₅₀ of 360 nM against human PKCβ1. Endoxifen Z-isomer also acts as an estrogen receptor modulator and antiestrogen. Endoxifen Z-isomer binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen Z-isomer inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. Endoxifen Z-isomer can be used in research related to ER ⁺ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors .

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3

L-Pyroglutamic acid sodium

3 Cited Publications

Cat. No.: HY-76082A

CAS No.: 28874-51-3

Category:

Alkaloids Pyrrole Alkaloids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

L-Pyroglutamic acid sodium is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid sodium is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. L-Pyroglutamic acid sodium can be used as a biomarker for systemic lupus erythematosus (SLE) .

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3

Endoxifen (Z-isomer hydrochloride)

3 Cited Publications

Cat. No.: HY-18719A

CAS No.: 1032008-74-4

Target:

PKC Estrogen Receptor/ERR PI3K Akt mTOR Apoptosis Reactive Oxygen Species (ROS)

Endoxifen Z-isomer hydrochloride is an orally active selective PKCβ1 inhibitor with an IC₅₀ of 360 nM against human PKCβ1. It also acts as an estrogen receptor modulator and antiestrogen. Endoxifen Z-isomer hydrochloride binds to and blocks ERα, ERβ and PKCβ1, inhibits estrogen and PI3K/AKT/mTORC1 signaling pathways, suppresses the expression of genes associated with cell cycle, cell proliferation and extracellular matrix remodeling, and induces apoptosis, reactive oxygen species (ROS) production and hypoxic features. Endoxifen Z-isomer hydrochloride inhibits tumor growth in breast tumor and glioblastoma models, reduces bone turnover and blood lipid levels, and does not require metabolism via CYP2D6. It can be used in research related to ER ⁺ breast cancer, invasive breast cancer, glioblastoma multiforme, type I bipolar disorder, desmoid tumor, gynecological malignancies, melanoma and hormone receptor-positive solid tumors .

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3

N-Acetyl-D-glucosamine

3 Cited Publications

Cat. No.: HY-A0132

CAS No.: 7512-17-6

Synonyms: N-Acetyl-2-amino-2-deoxy-D-glucose

Category:

Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides

Target:

Endogenous Metabolite Drug Derivative Drug Isomer Interleukin Related

N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .

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