14

Dexamethasone phosphate disodium

14 Publications Verification

Cat. No.: HY-B1829A

CAS No.: 2392-39-4

Synonyms: Dexamethasone 21-phosphate disodium

Target:

Glucocorticoid Receptor TGF-β Receptor Interleukin Related

Research Areas:

Neurological Disease Inflammation/Immunology

Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

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14

Dexamethasone phosphate

14 Publications Verification

Cat. No.: HY-B1829

CAS No.: 312-93-6

Synonyms: Dexamethasone 21-phosphate

Target:

Glucocorticoid Receptor TGF-β Receptor Interleukin Related

Research Areas:

Neurological Disease Inflammation/Immunology

Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

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11

Penfluridol

11 Cited Publications

Cat. No.: HY-B1077

CAS No.: 26864-56-2

Synonyms: R-16341

Target:

Calcium Channel Dopamine Receptor Autophagy Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 μg/ml .

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10

Dextran sulfate sodium salt (MW 35000-45000)

10 Cited Publications

Cat. No.: HY-116282C

CAS No.: 9011-18-1

Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000)

Target:

Apoptosis

Research Areas:

Infection Inflammation/Immunology Cancer

Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .

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4

(±)-Naringenin

4 Cited Publications

Cat. No.: HY-W011641

CAS No.: 67604-48-2

Category:

Cardiovascular Disease Flavonoids Flavonones Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:

Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase

(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

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