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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
acyl-enzyme
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "acyl-enzyme" in MCE Product Catalog:
1
1 Cited Publications
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APOL1-IN-1 is a natural product antibiotic and selective FabF inhibitor discovered in Streptomyces platensis. Platensimycin exhibits IC50 values of 48 nM and 160 nM against Staphylococcus aureus and Escherichia coli FabF, respectively. Platensimycin preferentially recognizes the acyl-enzyme conformation of FabF, occupies the malonyl-binding subsite, and competes with malonyl-ACP, thereby inhibiting bacterial fatty acid elongation. Platensimycin is useful for research on bacterial fatty acid biosynthesis and Gram-positive bacterial infections .
Cat. No.: HY-E70437
CAS No.: 80146-85-6
Synonyms: Tissue-type transglutaminase; TG2; TGase 2
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Guinea pig liver transglutaminase (Tissue-type transglutaminase) is a calcium-dependent tissue-type transglutaminase and serves as the prototype of intracellular tissue transglutaminases purified from guinea pig liver. Guinea pig liver transglutaminase catalyzes acyl transfer reactions via a ping-pong mechanism, forming a transient thioester acyl-enzyme intermediate that mediates the hydrolysis of glutamine amides, displacement by primary amines, and the formation of isopeptide cross-links between peptide-bound glutamine and the amino groups of lysine or polyamines .
Cat. No.: HY-P4477
CAS No.: 131068-47-8
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Cat. No.: HY-P5510
CAS No.: 188530-20-3
Synonyms: HCV NS3 protease substrate
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Cat. No.: HY-190300
CAS No.: 96666-80-7
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Serine Protease-IN-1 is a serine protease inhibitor. Serine Protease-IN-1 inhibits α-chymotrypsin activity with a Ki of 52.5 nM. Serine Protease-IN-1 acylates the active-site serine to form an acyl-enzyme intermediate that deacylates slowly .
Cat. No.: HY-187894
CAS No.: 189448-35-9
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RWJ-333441 is a PBP2a inhibitor that forms long-lived covalent acyl-enzymes with penicillin-binding proteins, thereby blocking bacterial cell wall synthesis. RWJ-333441 has antibacterial activity. RWJ-333441 can be used in research on severe Gram-positive infections, including methicillin-resistant Staphylococcus aureus infections .
Cat. No.: HY-124714
CAS No.: 2222059-70-1
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DKFZ-251 is a kininogenase-related peptidase KLK6 inhibitor (IC50=0.47 μM), and also exhibits certain inhibitory activity against KLK5 and KLK7 (IC50 values are 1.1 nM and 73 nM, respectively). DKFZ-251 transiently acylates the catalytic serine of KLK6 to form a long-lived acyl-enzyme complex that inhibits enzyme function. DKFZ-251 is a phenotypic modulator that alters cell proliferation capacity and regulates epithelial-mesenchymal transition (EMT). DKFZ-251 can be used in research related to head and neck cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
