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IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC₅₀ of 40 nM for the gatekeeper mutant ^M82FCK1δ .

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34

A 922500

34 Cited Publications

Cat. No.: HY-10038

CAS No.: 959122-11-3

Purity: 99.33%

Synonyms: DGAT-1 Inhibitor 4a

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A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of 9 and 22 nM against human and mouse DGAT-1, respectively.

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32

PF-06424439

32 Cited Publications

Cat. No.: HY-108341

CAS No.: 1469284-78-3

Purity: 99.89%

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PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM . PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

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32

PF-06424439 methanesulfonate

32 Cited Publications

Cat. No.: HY-108341A

CAS No.: 1469284-79-4

Purity: 99.85%

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Research Areas:

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM . PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

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20

Avasimibe

20 Cited Publications

Cat. No.: HY-13215

CAS No.: 166518-60-1

Purity: 99.77%

Synonyms: CI-1011; PD-148515

Target:

Research Areas:

Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC₅₀s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively . Avasimibe can be used for the research of prostate cancer .

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15

T863

15 Cited Publications

Cat. No.: HY-32219

CAS No.: 701232-20-4

Target:

Research Areas:

Infection Human Gut Microbiota Metabolites Microorganisms Antibiotics Disease Research Antibacterial Endogenous metabolite Disease Research Fields Other Antibiotics

T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC₅₀ of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells .

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10

Fumonisin B1

10 Cited Publications

Cat. No.: HY-N6719

CAS No.: 116355-83-0

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Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

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9

PF-04620110

9 Cited Publications

Cat. No.: HY-13009

CAS No.: 1109276-89-2

Purity: 99.60%

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PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC₅₀ of 19 nM .

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7

K-604 dihydrochloride

7 Cited Publications

Cat. No.: HY-100400A

CAS No.: 217094-32-1

Purity: 99.42%

Target:

Acyltransferase Apoptosis

Research Areas:

Cardiovascular Disease

K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC₅₀ of 0.45±0.06 μM.

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5

Nevanimibe

5 Cited Publications

Cat. No.: HY-100399

CAS No.: 133825-80-6

Synonyms: PD-132301; ATR-101

Target:

Research Areas:

Acyltransferase Apoptosis

Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .

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5

Nevanimibe hydrochloride

5 Cited Publications

Cat. No.: HY-100399A

CAS No.: 133825-81-7

Purity: 99.49%

Synonyms: PD-132301 hydrochloride; ATR101 hydrochloride

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Research Areas: