20

20 Publications Verification

Purity: 99.35%

Synonyms: 4-HNE

Category:

Neurological Disease Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:

Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite

4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

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19

Azoxymethane

19 Cited Publications

Cat. No.: HY-111375

CAS No.: 25843-45-2

Synonyms: AOM

Target:

DNA Alkylator/Crosslinker

Research Areas:

Cancer

Azoxymethane (AOM) is a colon carcinogen which leads to the formation of DNA adducts. Azomethane is a procarcinogen that requires metabolic activation via cytochrome P450 (P450) enzymes (primarily CYP2E1) .

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4

Norfloxacin (nicotinate)

4 Cited Publications

Cat. No.: HY-B0132B

CAS No.: 118803-81-9

Synonyms: MK-0366 (nicotinate)

Target:

Bacterial Antibiotic

Research Areas:

Infection

Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration .

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3

Dansyl chloride

3 Cited Publications

Cat. No.: HY-D0017

CAS No.: 605-65-2

Synonyms: DNSCl

Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis .

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3

N-tert-Butyl-α-phenylnitrone

3 Cited Publications

Cat. No.: HY-128463

CAS No.: 3376-24-7

Purity: 99.94%

Target:

Free Radical Scavengers COX Reactive Oxygen Species (ROS)

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology

N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .

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2

2-Hydroxyestradiol

2 Cited Publications

Cat. No.: HY-124489

CAS No.: 362-05-0

Purity: ≥97.0%

Category:

Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

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2

Zinquin ethyl ester

2 Cited Publications

Cat. No.: HY-124171

CAS No.: 181530-09-6

Purity: ≥99.0%

Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn ²⁺ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm) .

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2

Paracetamol-cysteine TFA

2 Cited Publications

Cat. No.: HY-139093A

CAS No.: 1331891-93-0

Purity: ≥99.0%

Synonyms: APAP-Cys TFA

Target:

Drug Derivative

Research Areas:

Others

Paracetamol-cysteine TFA (APAP-Cys TFA) is a cysteine adduct of Acetaminophen (HY-66005). It forms when Acetaminophen is oxidized to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI) .

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2

2,6-Dithiopurine

2 Cited Publications

Cat. No.: HY-W016286

CAS No.: 5437-25-2

Synonyms: 2,6-Dimercaptopurine

Target:

Biochemical Assay Reagents

Research Areas:

Cancer

2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .

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2

CCG-50014

2 Cited Publications

Cat. No.: HY-13509

CAS No.: 883050-24-6

Purity: 99.62%

Target:

RGS Protein

Research Areas:

Inflammation/Immunology

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC₅₀ =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .

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2

TAK-418

2 Cited Publications

Cat. No.: HY-138830

CAS No.: 1818252-53-7

Purity: 99.81%

Target:

Histone Demethylase

Research Areas:

Neurological Disease

TAK-418 is an orally active, blood-brain barrier-penetrant LSD1 inhibitor with a human IC₅₀ of 2.9 nM. TAK-418 irreversibly inhibits LSD1 by forming a compact flavin-FAD adduct with the catalytic domain FAD, blocking the demethylation of H3K4me1/2 and H3K9me1/2 without disrupting the LSD1-GFI1B interaction. TAK-418 restores normally dysregulated brain gene expression and DNA methylation, increases H3K4me1/2/3 and H3K9me2 at the Ucp2 locus, and induces Ucp2 mRNA expression. TAK-418 rescues defective H3K4 histone modifications, normalizes adult neurogenesis, and improves recognition memory, social behavior, and cognition in rodent models. TAK-418 can be used in research related to neurodevelopmental disorders, Alzheimer's disease, and autism spectrum disorders .

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1

D-Glyceraldehyde 3-phosphate

1 Cited Publications

Cat. No.: HY-151223

CAS No.: 591-57-1

Purity: 99.84%

Synonyms: Triose phosphate

Category:

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Fructose-1,6-bisphosphate aldolase Endogenous Metabolite

D-Glyceraldehyde 3-phosphate (Triose phosphate) is a key intermediate in glycolysis and gluconeogenesis, as well as a carbohydrate product of the Calvin cycle. D-Glyceraldehyde 3-phosphate participates in the biosynthesis of tryptophan and thiamine. D-Glyceraldehyde 3-phosphate is released as an aldehyde under the action of aldolase or triosephosphate isomerase. D-Glyceraldehyde 3-phosphate forms adducts with thiols .

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1

Aristolochic acid B

1 Cited Publications

Cat. No.: HY-N0511

CAS No.: 475-80-9

Synonyms: Aristolochic acid II

Category:

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:

DNA Alkylator/Crosslinker

Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA). Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510) .

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1

Isopimpinellin

1 Cited Publications

Cat. No.: HY-N0769

CAS No.: 482-27-9

Category:

Coumarins Plants Infection Microorganisms 500 - Internal Server Error | MedChemExpress

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