82 Results for "

adjuvant activity

" in MedChemExpress (MCE) Product Catalog:
Products (82)

82 Results for "adjuvant activity" in MCE Product Catalog:

68
Poly (I:C):Kanamycin (1:1) sodium
Poly (I:C):Kanamycin (1:1) sodium
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68 Publications Verification
Cat. No.: HY-135748A
Target:  

RIG-I-like receptor (RLR) Toll-like Receptor (TLR) Apoptosis

Research Areas:  

Infection Cancer

Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .
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18
Diprovocim
Diprovocim
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18 Cited Publications
Cat. No.: HY-123942
CAS No.: 2170867-89-5
Purity:  98.82%
Target:  

Toll-like Receptor (TLR) TNF Receptor p38 MAPK NF-κB

Research Areas:  

Inflammation/Immunology Cancer

Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC50=110 pM). Diprovocim stimulates the release of TNF-α from mouse macrophages (EC50=1.3 nM). Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses .
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9
Ritlecitinib
Ritlecitinib
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9 Cited Publications
Cat. No.: HY-100754
CAS No.: 1792180-81-4
Purity:  99.43%
Synonyms: PF-06651600
Target:  

JAK Interleukin Related STAT

Research Areas:  

Inflammation/Immunology

Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
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9
Ritlecitinib tosylate
Ritlecitinib tosylate
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9 Cited Publications
Cat. No.: HY-100754C
CAS No.: 2192215-81-7
Purity:  99.77%
Synonyms: PF-06651600 tosylate
Target:  

JAK Interleukin Related STAT

Research Areas:  

Inflammation/Immunology

Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .
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7
Surfactin
Surfactin
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7 Cited Publications
Cat. No.: HY-129555
CAS No.: 252023-70-4
Purity:  98.96%
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

Bacterial HSV Antibiotic

Surfactin is a potent cyclic lipopeptide biosurfactants consists of four isomers (Surfactin A, B, C and D), which mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects . Surfactin also has antiviral activity against a variety of enveloped viruses .
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4
C6 Ceramide
C6 Ceramide
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4 Cited Publications
Cat. No.: HY-19542
CAS No.: 124753-97-5
Synonyms: C6-Cer; N-Hexanoylsphingosine
Target:  

Apoptosis

Research Areas:  

Cancer

C6 Ceramide (C6-Cer) is a short-chain, cell-permeable ceramide pathway activator with anticancer activity. C6 Ceramide-mediated miR-29b expression participates in the progression of multiple myeloma through suppressing the proliferation, migration and angiogenesis of endothelial cells by targeting Akt signal pathway. C6 Ceramide exhibits multiple anti-cancer properties including cell cycle arrest, Apoptosis, inhibition of tumor growth and enhances the effects of chemotherapy in drug-resistant cancer cells. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .
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4
9-Aminoacridine
9-Aminoacridine
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4 Cited Publications
Cat. No.: HY-B1422
CAS No.: 90-45-9
Synonyms: Aminacrine
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
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3
Platycodin D2
Platycodin D2
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3 Cited Publications
Cat. No.: HY-N4087
CAS No.: 66663-90-9
Category:  

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