Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
adrenal cortex
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "adrenal cortex" in MCE Product Catalog:
95
72
72 Cited Publications
Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
11
Target:
7
Research Areas:
Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
1
1
1 Cited Publications
Cat. No.: HY-W013215
CAS No.: 28874-58-0
Synonyms: cis-7,10,13,16-Docosatetraenoic acid
Category:
Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
1
1 Cited Publications
Synonyms: ACTH; Adrenocorticotrophic hormone
Target:
Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor
Research Areas:
1
1 Cited Publications
Cat. No.: HY-106373A
Purity: 99.85%
Synonyms: ACTH TFA; Adrenocorticotrophic hormone TFA
Target:
Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor
Research Areas:
Cat. No.: HY-N0583S2
CAS No.: 73565-87-4
Synonyms: Cortisol-d4
Cat. No.: HY-N0583S1
Synonyms: Cortisol-d7
Synonyms: 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)
Cat. No.: HY-113313S1
Purity: 99.78%
Cat. No.: HY-N0583S5
CAS No.: 1257650-73-9
Synonyms: Cortisol-d2
Cat. No.: HY-N0583S3
CAS No.: 115699-92-8
Synonyms: Cortisol-d3
Target:
Cat. No.: HY-113313R
CAS No.: 52-39-1
Cat. No.: HY-P10278
CAS No.: 133658-45-4
Target:
Research Areas:
Cat. No.: HY-B0561S4
Cat. No.: HY-P1558B
CAS No.: 79190-56-0
Synonyms: Adrenocorticotropic Hormone (11-24) hexaacetate
Target:
Research Areas:
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
