170

Disulfiram

170 Publications Verification

Cat. No.: HY-B0240

CAS No.: 97-77-8

Synonyms: Tetraethylthiuram disulfide; TETD

Target:

Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis

Research Areas:

Metabolic Disease Cancer

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

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25

NADPH tetrasodium salt

25 Cited Publications

Cat. No.: HY-F0003

CAS No.: 2646-71-1

Target:

Ferroptosis Endogenous Metabolite

Research Areas:

Metabolic Disease Cancer

NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication .

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25

NADPH tetracyclohexanamine

25 Cited Publications

Cat. No.: HY-F0003A

CAS No.: 100929-71-3

Target:

Ferroptosis Endogenous Metabolite

Research Areas:

Metabolic Disease Cancer

NADPH tetracyclohexanamine functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetracyclohexanamine is an endogenous inhibitor of ferroptosis. NADPH tetracyclohexanamine plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication .

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22

Haloperidol

22 Cited Publications

Cat. No.: HY-14538

CAS No.: 52-86-8

Purity: 99.73%

Target:

Dopamine Receptor

Research Areas:

Neurological Disease Cancer

Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic agent. Haloperidol can be used in the study of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal.

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22

Haloperidol hydrochloride

22 Cited Publications

Cat. No.: HY-14538A

CAS No.: 1511-16-6

Target:

Dopamine Receptor

Research Areas:

Neurological Disease Cancer

Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic agent. Haloperidol hydrochloride can be used in the study of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal.

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21

Tribromoethyl alcohol

21 Cited Publications

Cat. No.: HY-B1372

CAS No.: 75-80-9

Synonyms: 2,2,2-Tribromoethanol; Narcolan

Target:

Biochemical Assay Reagents

Research Areas:

Neurological Disease

Tribromoethyl alcohol (2,2,2-Tribromoethanol) is used to animals, particularly rodents, before surgery.

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18

Prazosin hydrochloride

18 Cited Publications

Cat. No.: HY-B0193A

CAS No.: 19237-84-4

Target:

Adrenergic Receptor Autophagy

Research Areas:

Cardiovascular Disease Endocrinology Cancer

Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC₅₀ of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC₅₀s of 1.8, and 13 μM, respectively .

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16

Tempo

16 Cited Publications

Cat. No.: HY-W001187

CAS No.: 2564-83-2

Target:

Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species (ROS)

Research Areas:

Cancer

Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .

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12

Nitrosoglutathione

12 Cited Publications

Cat. No.: HY-D0845

CAS No.: 57564-91-7

Synonyms: GSNO; RVC-588; S-Nitroso-L-glutathione

Target:

Endogenous Metabolite Angiotensin Receptor

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses .

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