10430 Results for "

aldehyde volatile compound

" in MedChemExpress (MCE) Product Catalog:

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2335

MG-132

2335 Publications Verification

Cat. No.: HY-13259

CAS No.: 133407-82-6

Purity: 99.90%

Synonyms: Z-Leu-Leu-Leu-al; MG132

Target:

Proteasome Autophagy Apoptosis

Research Areas:

Cancer

MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC₅₀s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activator. MG-132 also induces apoptosis .

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843

Dorsomorphin dihydrochloride

843 Cited Publications

Cat. No.: HY-13418

CAS No.: 1219168-18-9

Purity: 99.7%

Synonyms: BML-275 dihydrochloride; compound C dihydrochloride

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a K_i of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).

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843

Dorsomorphin

843 Cited Publications

Cat. No.: HY-13418A

CAS No.: 866405-64-3

Purity: 99.10%

Synonyms: BML-275; compound C

Target:

Organoid AMPK TGF-β Receptor Autophagy

Research Areas:

Inflammation/Immunology Cancer

Dorsomorphin (BML-275; Compound C) is a selective and ATP-competitive AMPK inhibitor (K_i=109 nM in the absence of AMP). Dorsomorphin selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599) .

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170

Disulfiram

170 Cited Publications

Cat. No.: HY-B0240

CAS No.: 97-77-8

Synonyms: Tetraethylthiuram disulfide; TETD

Target:

Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis

Research Areas:

Metabolic Disease Cancer

Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

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Cy5.5

78 Cited Publications

Cat. No.: HY-D0924

CAS No.: 210892-23-2

Synonyms: Sulfo-Cyanine5.5

Target:

Fluorescent Dye

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cy5.5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

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Corticosterone

72 Cited Publications

Cat. No.: HY-B1618

CAS No.: 50-22-6

Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B

Category:

Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:

Glucocorticoid Receptor Endogenous Metabolite iGluR

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

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Elexacaftor

56 Cited Publications

Cat. No.: HY-111772

CAS No.: 2216712-66-0

Purity: 99.74%

Synonyms: VX-445

Target:

CFTR Autophagy

Research Areas:

Inflammation/Immunology

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .

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Doramapimod hydrochloride

56 Cited Publications

Cat. No.: HY-10320A

CAS No.: 1283526-53-3

Synonyms: BIRB 796 hydrochloride

Target:

Autophagy Raf p38 MAPK

Research Areas:

Inflammation/Immunology

Doramapimod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound with biological activity through inhibition of p38 MAPK. Doramapimod hydrochloride can significantly inhibit the activities of TNF-α and IL-1β induced by LPS, LTA and PGN. Doramapimod hydrochloride showed a stronger inhibitory effect on inflammation induced by all three bacterial toxins, which was more significant compared with the effects of other compounds. Doramapimod hydrochloride can be used in the research of autoimmune diseases .

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CY5

50 Cited Publications

Cat. No.: HY-D0821

CAS No.: 146368-11-8

Synonyms: Sulfo-Cyanine5

Target:

Fluorescent Dye

Research Areas:

Cancer

CY5 is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .

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