213

Temozolomide

213 Publications Verification

Cat. No.: HY-17364

CAS No.: 85622-93-1

Synonyms: NSC 362856; CCRG 81045; TMZ

Target:

DNA Alkylator/Crosslinker Autophagy Apoptosis

Research Areas:

Cancer

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

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86

Cyclophosphamide

86 Cited Publications

Cat. No.: HY-17420

CAS No.: 50-18-0

Target:

DNA Alkylator/Crosslinker

Research Areas:

Cancer

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

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86

Cyclophosphamide hydrate

86 Cited Publications

Cat. No.: HY-17420A

CAS No.: 6055-19-2

Synonyms: Cyclophosphamide monohydrate

Target:

DNA Alkylator/Crosslinker

Research Areas:

Cancer

Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

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24

N-Nitroso-N-methylurea

24 Cited Publications

Cat. No.: HY-34758

CAS No.: 684-93-5

Target:

Environmental Pollutants DNA Alkylator/Crosslinker

Research Areas:

Cancer

N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .

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21

Busulfan

21 Cited Publications

Cat. No.: HY-B0245

CAS No.: 55-98-1

Target:

DNA Alkylator/Crosslinker Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

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16

Dacarbazine

16 Cited Publications

Cat. No.: HY-B0078

CAS No.: 4342-03-4

Synonyms: Imidazole Carboxamide

Target:

Nucleoside Antimetabolite/Analog Apoptosis

Research Areas:

Cancer

Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC₅₀ of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .

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15

Methylnitronitrosoguanidine

15 Cited Publications

Cat. No.: HY-128612

CAS No.: 70-25-7

Purity: 99.96%

Synonyms: MNNG

Target:

DNA Alkylator/Crosslinker

Research Areas:

Cancer

Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.

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14

2-Iodoacetamide

14 Cited Publications

Cat. No.: HY-34477

CAS No.: 144-48-9

Synonyms: Iodoacetamide

Target:

DNA Alkylator/Crosslinker

Research Areas:

Others

2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .

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10

Ifosfamide

10 Cited Publications

Cat. No.: HY-17419

CAS No.: 3778-73-2

Target:

DNA Alkylator/Crosslinker

Research Areas:

Neurological Disease Cancer

Ifosfamide is a CNS-penetrant alkylating chemotherapeutic agent with activity against a wide range of tumors.

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8

Lomustine

8 Cited Publications

Cat. No.: HY-13669

CAS No.: 13010-47-4

Purity: 99.90%

Synonyms: CCNU; NSC 79037

Target:

DNA Alkylator/Crosslinker Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.

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7

Bendamustine hydrochloride

7 Cited Publications

Cat. No.: HY-B0077

CAS No.: 3543-75-7

Synonyms: SDX-105

Target:

DNA Alkylator/Crosslinker Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

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7

Bendamustine

7 Cited Publications

Cat. No.: HY-13567

CAS No.: 16506-27-7

Purity: ≥98.0%

Synonyms: SDX-105 free base

Target:

DNA Alkylator/Crosslinker Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

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7

Isoalantolactone

7 Cited Publications

Cat. No.: HY-N0780

CAS No.: 470-17-7

Synonyms: (+)-Isoalantolactone; Isohelenin

Category:

Terpenoids Sesquiterpenes 500 - Internal Server Error | MedChemExpress

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