183

Docetaxel

183 Publications Verification

Cat. No.: HY-B0011

CAS No.: 114977-28-5

Synonyms: RP-56976

Category:

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

183

Docetaxel Trihydrate

183 Publications Verification

Cat. No.: HY-B0011A

CAS No.: 148408-66-6

Synonyms: RP-56976 Trihydrate

Target:

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

39

Temuterkib

39 Cited Publications

Cat. No.: HY-101494

CAS No.: 1951483-29-6

Purity: 99.94%

Synonyms: LY3214996

Target:

ERK

Research Areas:

Cancer

Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC₅₀ of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

28

Filipin III

28 Cited Publications

Cat. No.: HY-N6718

CAS No.: 480-49-9

Category:

Microorganisms Antifungal Antibiotics Disease Research Disease Research Fields Inflammation/Immunology Other Antibiotics

Target:

Antibiotic Fungal

Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

17

CTPI-2

17 Cited Publications

Cat. No.: HY-123986

CAS No.: 68003-38-3

Purity: 99.95%

Target:

Mitochondrial Metabolism

Research Areas:

Inflammation/Immunology Cancer

CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a K_D of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

13

Elrelesertib

13 Cited Publications

Cat. No.: HY-109566

CAS No.: 2089288-03-7

Purity: 99.22%

Synonyms: AZD1390

Target:

ATM/ATR Apoptosis Checkpoint Kinase (Chk)

Research Areas:

Cancer

Elrelesertib (AZD1390) is an orally active, brain-penetrant ATM kinase inhibitor with IC₅₀ values of 0.78 nM. Elrelesertib blocks ATM-dependent DNA damage response, inhibits ATM autophosphorylation and downstream Chk2, Rad50 phosphorylation, and accumulates at DNA breaks. Elrelesertib acts as a radiosensitizer, induces apoptosis, genomic instability, G2-M cell cycle arrest, ROS elevation, and mitochondrial membrane potential alteration. Elrelesertib has low efflux liability against P-gp and BCRP. Elrelesertib can be used for the research of central nervous system malignancies, glioblastoma multiforme, glioma, lung cancer brain metastases, and breast cancer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

10

Alendronic acid

10 Cited Publications

Cat. No.: HY-B0631

CAS No.: 66376-36-1

Target:

NF-κB Interleukin Related

Research Areas:

Metabolic Disease

Alendronate acid is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate acid induces skeletal alterations in the chicken embryonic development model. Alendronate acid can be used for osteoporosis research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

10

Alendronate sodium

10 Cited Publications

Cat. No.: HY-108685

CAS No.: 129318-43-0

Purity: ≥98.0%

Synonyms: Alendronic acid monosodium salt

Target:

NF-κB Interleukin Related

Research Areas:

Metabolic Disease

Alendronate sodium is an orally active bisphosphonate which binds to bone surfaces and inhibits bone resorption by osteoclasts. Alendronate sodium induces skeletal alterations in the chicken embryonic development model. Alendronate sodium can be used for osteoporosis research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Umbelliferone

5 Cited Publications

Cat. No.: HY-N0573

CAS No.: 93-35-6

Synonyms: 7-Hydroxycoumarin; Hydrangin; NSC 19790

Category:

Monophenols Coumarins Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer

Target:

Apoptosis Fluorescent Dye

Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Lincomycin

5 Cited Publications

Cat. No.: HY-117660

CAS No.: 154-21-2

Purity: 99.82%

Synonyms: U-10149

Category:

Infection Alkaloids Microorganisms Pyrrole Alkaloids Disease Research Fields

Target:

Antibiotic Bacterial DNA/RNA Synthesis

Lincomycin (U-10149) is an orally active lincosamide antibiotic. Lincomycin binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Lincomycin hydrochloride

5 Cited Publications

Cat. No.: HY-B0417A

CAS No.: 859-18-7

Synonyms: U10149A

Category:

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics Plant agriculture research

Target:

DNA/RNA Synthesis Antibiotic Bacterial

Lincomycin hydrochloride (U10149A) is an orally active lincosamide antibiotic. Lincomycin hydrochloride binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Lincomycin hydrochloride monohydrate

5 Cited Publications

Cat. No.: HY-B1358

CAS No.: 7179-49-9

Synonyms: U-10149 hydrochloride monohydrate

Category:

Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics Plant agriculture research

Target:

DNA/RNA Synthesis Antibiotic Bacterial

Lincomycin (U-10149) hydrochloride monohydrate is an orally active lincosamide antibiotic. Lincomycin hydrochloride monohydrate binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride monohydrate can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride monohydrate induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

MitoTEMPOL

4 Cited Publications

Cat. No.: HY-115386

CAS No.: 1101113-39-6

Purity: 98.00%

Target:

Reactive Oxygen Species (ROS) Autophagy Ferroptosis

Research Areas:

Infection Metabolic Disease Inflammation/Immunology

MitoTEMPOL is a mitochondria-targeted superoxide scavenger. MitoTEMPOL accumulates in mitochondria via membrane potential and locally scavenges superoxide anions. MitoTEMPOL alleviates hepatic oxidative stress and alterations in genes related to autophagy in STZ (HY-13753)-induced diabetic models. MitoTEMPOL inhibits diaphragmatic mitochondrial dysfunction and activation of proteolytic pathways in sepsis models. MitoTEMPOL also alleviates AGEs (HY-NP165)-induced ferritinophagy-dependent ferroptosis in human umbilical vein endothelial cells. MitoTEMPOL is used in research related to diabetes, sepsis, and vascular endothelial ferroptosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Lirafugratinib

2 Cited Publications

Cat. No.: HY-147250

CAS No.: 2549174-42-5

Purity: 99.67%

Synonyms: RLY-4008

Target:

FGFR

Research Areas:

Cancer

Lirafugratinib (RLY-4008) is an orally active, irreversible and highly selective FGFR2 inhibitor with an IC₅₀ of 3 nM. Lirafugratinib covalently binds to Cys491. Lirafugratinib targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Lirafugratinib hydrochloride

2 Cited Publications

Cat. No.: HY-147250A

CAS No.: 2688040-45-9

Purity: 98.96%

Synonyms: RLY-4008 hydrochloride

Target:

FGFR

Research Areas:

Cancer

Lirafugratinib (RLY-4008) hydrochloride is an orally active, irreversible and highly selective FGFR2 inhibitor with an IC₅₀ of 3 nM. Lirafugratinib hydrochloride covalently binds to Cys491. Lirafugratinib hydrochloride targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Ganoderic acid F

1 Cited Publications

Cat. No.: HY-N6036

CAS No.: 98665-15-7

Category:

Triterpenes Microorganisms Terpenoids Polyporaceae Extract 500 - Internal Server Error | MedChemExpress

country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Cart

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.