14

PX-12

14 Publications Verification

Cat. No.: HY-13734

CAS No.: 141400-58-0

Purity: 99.87%

Synonyms: IV-2

Target:

Apoptosis

Research Areas:

Cancer

PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC₅₀ values of 1.9 and 2.9 μM, respectively.

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11

STAT3-IN-1

11 Cited Publications

Cat. No.: HY-100753

CAS No.: 2059952-75-7

Purity: 96.28%

Target:

STAT Apoptosis

Research Areas:

Cancer

STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC₅₀ values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis .

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4

LY3509754

4 Cited Publications

Cat. No.: HY-139206

CAS No.: 2452464-73-0

Purity: 99.65%

Synonyms: IL-17A inhibitor 1

Target:

Interleukin Related

Research Areas:

Inflammation/Immunology

LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC₅₀ values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells .

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4

Lys05

4 Cited Publications

Cat. No.: HY-12855A

CAS No.: 1391426-24-6

Purity: 99.89%

Synonyms: Lys01 trihydrochloride

Target:

Autophagy

Research Areas:

Cancer

Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC₅₀ values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

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4

TC13172

4 Cited Publications

Cat. No.: HY-101524

CAS No.: 2093393-05-4

Purity: 99.04%

Target:

Mixed Lineage Kinase

Research Areas:

Cancer

TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC₅₀ value of 2 nM for HT-29 cells .

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4

Plinabulin

4 Cited Publications

Cat. No.: HY-14444

CAS No.: 714272-27-2

Purity: ≥98.0%

Synonyms: NPI-2358

Target:

Microtubule/Tubulin

Research Areas:

Cancer

Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC₅₀ of 9.8 nM against HT-29 cells . Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells .

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1

DPI-4452

1 Cited Publications

Cat. No.: HY-P10761

CAS No.: 2941391-49-5

Target:

Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase

Research Areas:

Cancer

DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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1

SR 142948

1 Cited Publications

Cat. No.: HY-107664

CAS No.: 184162-64-9

Purity: 99.16%

Target:

Neuropeptide Y Receptor

Research Areas:

Neurological Disease

SR 142948 is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC₅₀s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders .

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