246

Enzalutamide

246 Publications Verification

Cat. No.: HY-70002

CAS No.: 915087-33-1

Synonyms: MDV3100

Target:

Androgen Receptor Autophagy

Research Areas:

Cancer

Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC₅₀ of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator .

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64

DHEA

64 Cited Publications

Cat. No.: HY-14650

CAS No.: 53-43-0

Purity: 99.93%

Synonyms: Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone

Category:

Human Gut Microbiota Metabolites Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Environmental Pollutants Endogenous Metabolite Androgen Receptor

DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

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36

Medroxyprogesterone acetate

36 Cited Publications

Cat. No.: HY-B0469

CAS No.: 71-58-9

Synonyms: Medroxyprogesterone 17-acetate; Farlutin

Target:

Progesterone Receptor Androgen Receptor Glucocorticoid Receptor

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

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22

Estradiol benzoate

22 Cited Publications

Cat. No.: HY-B1192

CAS No.: 50-50-0

Synonyms: β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate

Category:

Disease Research Fields Cancer

Target:

Estrogen Receptor/ERR HBV Bcl-2 Family

Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

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21

Bicalutamide

21 Cited Publications

Cat. No.: HY-14249

CAS No.: 90357-06-5

Purity: 99.91%

Target:

Androgen Receptor Autophagy

Research Areas:

Cancer

Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .

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21

BAY-3827

21 Cited Publications

Cat. No.: HY-112083

CAS No.: 2377576-35-5

Purity: 99.66%

Target:

AMPK

Research Areas:

Cancer

BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC₅₀ values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines .

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